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ABC522 Anti-MATE1 Antibody

ABC522
200 µL  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC522
      DescriptionAnti-MATE1 Antibody
      Alternate Names
      • MATE1
      • Multidrug and toxin extrusion protein 1
      • MATE-1
      • hMATE-1
      • Solute carrier family 47 member 1
      Background InformationMATE1 is part of our innate metabolism and functions as multi-substrate small molecule transporter. MATE1 is widely expressed in many tissues and is found especially found in luminal membranes of urinary tubules, bile caniculi and brush border membranes. MATE1 is the cellular transporter for tetraethylammonium (TEA), 1-methyl-4-phenylpyridinium (MPP), cimetidine, N-methylnicotinamide (NMN), metformin, creatinine, guanidine, procainamide, topotecan, estrone sulfate, cephalosporin, cephalexin and cephradin, and MATE1 often mediates the final excretion step for toxic organic cations. In disease treatments, it also is the transporter for the uptake of various anti-cancer drugs like acyclovir and ganciclovir but also toxins like Paraquat (a potent herbicide).
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-MATE1 Antibody is an antibody against MATE1 for use in Western Blotting.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to the C-terminus of human MATE1.
      EpitopeC-terminus
      ConcentrationPlease refer to lot specific datasheet.
      HostRabbit
      SpecificityThis antibody is predicted to react to Isoform 1 and possible Isoform 3, but not isoform 2.
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • SLC47A1
      • MATE1
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~62 kDa observed. In some western blots, site-specific polyclonal antibodies against the C-terminal region of hMAT-1 revealed the broad immunoreactive protein band of the expected size ( 62 kDa) in human kidney membranes was observed (Otsuka, M, et al. (2005). PNAS. 102(50):17923-17928). Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human kidney tissue lysate.

      Western Blotting Analysis: A 1:250 dilution of this antibody detected MATE1 in 10 µg of human kidney tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      ABC522 04055977136234

      Documentation

      Anti-MATE1 Antibody Certificati d'Analisi

      TitoloNumero di lotto
      Anti-MATE1 -Q2553942 Q2553942

      Riferimenti bibliografici

      Panoramica dei riferimenti bibliograficiCodice d'identificazione nel Pub Med
      Proceedings of the National Academy of Sciences of the United States of America
      Otsuka, M; Matsumoto, T; Morimoto, R; Arioka, S; Omote, H; Moriyama, Y
      Proceedings of the National Academy of Sciences of the United States of America  102  17923-8  2004

      Mostra il sommario
      16330770 16330770

      Informazioni tecniche

      Titolo
      White Paper: Further considerations of antibody validation and usage.