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MABF2055-25UG Anti-IDO-2 Antibody, clone 4-3

Anti-IDO-2, clone 4-3, Cat. No. MABF2055, is a mouse monoclonal antibody that detects IDO2 and has been tested for use in Western Blotting.

Anti-IDO-2 Antibody, clone 4-3: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Inflammation & Immunology Gene Symbol: Ido2, Indol1 UniProt Number: Q8R0V5
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MABF2055-25UG
25 μg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF2055-25UG
      DescriptionAnti-IDO-2 Antibody, clone 4-3
      Alternate Names
      • Indoleamine 2
      • 3-dioxygenase 2
      • Indoleamine 2
      • 3-dioxygenase-like protein 1
      • Indoleamine-pyrrole 2
      • 3-dioxygenase-like protein 1
      Background InformationIndoleamine 2,3-dioxygenase 2 (UniProt: Q8R0V5; also known as IDO-2, Indoleamine 2,3-dioxygenase-like protein 1, Indoleamine-pyrrole 2,3-dioxygenase-like protein 1) is encoded by the Ido2 (also known as Indol1) gene (Gene ID: 209176) in murine species. IDO-2 is expressed mainly in antigen-presenting immune cells, liver, kidney, brain, and placenta. It is highly expressed in kidney, followed by epididymis and liver and is also detected in the tails of the spermatozoa. It catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan catabolism. IDO-1 and IDO-2 are 2 distinct enzymes which catalyze the same reaction. However, the Km for IDO-2 for tryptophan is much higher than that of IDO-1. IDO-2 may play a role as a negative regulator of IDO-1 by competing for heme-binding with IDO-1. IDO-2 activity is inhibited by 1MT (1-methyl-tryptophan) and MTH-trp (methylthiohydantoin-DL-tryptophan). IDO-2 is also involved in immune regulation. IDO-2 knockout mice do not show any apparent defects in their embryonic development or hematopoietic differentiation and have wild-type profiles for kynurenine in blood serum and for immune cells in spleen, lymph nodes, peritoneum, thymus and bone marrow. However, the knockout mice exhibit defects in IDO-mediated T-cell regulation and inflammatory responses. (Ref.: Mbongue JC, et al. (2015). Vaccines (Basel). 3(3):703-29).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-IDO-2, clone 4-3, Cat. No. MABF2055, is a mouse monoclonal antibody that detects IDO2 and has been tested for use in Western Blotting.
      Key Applications
      • Western Blotting
      Application NotesWestern Blotting Analysis: 0.5 µg/mL from a represesntative lot detected IDO-2 in 10 µg of mouse kidney tissue lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide/recombinant protein corresponding to 21 amino acids from the C-terminal region of murine Indoleamine 2,3-dioxygenase 2 (IDO-2).
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 4-3 detects IDO-2 in mouse. It targets an epitope within 21 amino acids in the C-terminal region.
      IsotypeIgG1
      Species Reactivity
      • Mouse
      Species Reactivity NoteMouse.
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Ido2
      • Indol1
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight55 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse liver tissue lysate. Western Blotting Analysis: 0.5 µg/mL of this antibody detected IDO-2 in 10 µg of mouse liver tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size25 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABF2055-25UG 04054839476952