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MABN642 Anti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody

This Anti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GST Omega 1 (GSTO1).

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Research Category: Neuroscience Research Sub-Category: Developmental Signaling Gene Symbol: GSTO1, GSTTLP28 UniProt Number: P78417
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MABN642
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN642
      DescriptionAnti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody
      Alternate Names
      • Glutathione S-transferase omega-1
      • GSTO-1
      • Glutathione S-transferase omega 1-1
      • GSTO 1-1
      • Glutathione-dependent dehydroascorbate reductase
      • Monomethylarsonic acid reductase
      • MMA(V) reductase
      • S-(Phenacyl)glutathione reductase
      • SPG-R
      • GST Omega 1 (GSTO1)
      Background InformationGST Omega 1 (GSTO1), also known as Glutathione S-transferase omega-1,GSTO-1, Glutathione S-transferase omega 1-1, GSTO 1-1, Glutathione-dependent dehydroascorbate reductase, Monomethylarsonic acid reductase, MMA(V), or S-(Phenacyl)glutathione reductase, SPG-R, and encoded by the gene GSTO1/GSTTLP28, a ubiquitously expressed cytoplasmic enzyme that is highest in the liver and lowest in the brain It belongs to the GST superfamily of anti-oxidant reducing enzymes and is in the omega class. The omega class of glutathione transferases (GSTs) is a relatively ancient member of the cytosolic GST superfamily, and the omega-class GSTs are found in plants, animals, and some microbial species. The omega-class, unlike other GSTs, has a cysteine residue in their active site. Consequently, the omega-class GSTs catalyze a range of thiol transferase and reduction reactions that are not catalyzed by members of the other classes. GST Omega 1 (GSTO1) is involved in L-ascorbic acid metabolism, detoxification of arsenic substances, glutathione biosynthetic processes, regulation of ryanodine-sensitive calcium release channels, regulation of skeletal muscle contraction and the release of sequestered calcium in muscle, and xenobiotic catabolism. Interestingly genetic linkage studies have discovered associations between GSTO1 gene mutations and the age at onset of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, perhaps stemming from the capacity of omega-class GSTs to mitigate oxidative stress or their role in activating the proinflammatory cytokine, interleukin-1β.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-GST Omega 1 (GSTO1), clone 1H10.1 Antibody is validated for use in Western Blotting and Immunohistochemistry (Paraffin) for the detection of GST Omega 1 (GSTO1).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50-500 dilution from a representative lot detected GST Omega 1 (GSTO1) in human cerebral cortex and rat cerebellum tissue.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human GST Omega 1 (GSTO1).
      Clone1H10.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GSTO1
      • GSTTLP28
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~28 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human heart tissue lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected GST Omega 1 (GSTO1) in 200 µg of human heart tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABN642 04053252978852