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MABE444 Anti-GATA-binding factor 3 Antibody, clone 7E8.1

Anti-GATA-binding factor 3 Antibody, clone 7E8.1 is an antibody against GATA-binding factor 3 for use in Western Blotting, Immunohistochemistry (Paraffin).

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Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: GATA3, HDR, HDRS UniProt Number: P23771
MABE444
100 μg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABE444
      DescriptionAnti-GATA-binding factor 3 Antibody, clone 7E8.1
      Alternate Names
      • Trans-acting T-cell-specific transcription factor GATA-3
      • GATA-binding factor 3
      Background InformationTrans-acting T-cell-specific transcription factor GATA-3 (UniProt P23771; also known as GATA-binding factor 3) is encoded by the GATA3 (also known as HDR, HDRS) gene (Gene ID 2625) in human. GATA-3 is a zinc finger transcription factor family protein that plays an important role in the differentiation of Th2 T helper cells. GATA-3 mediates the transcription of Th2 cytokine genes, particularly IL-4, IL-5 and IL-13. GATA-3 activates the transcription of IL-5 and IL-13 by directly binding to their promoters, while GATA-3 indirectly regulates IL-4 transcription by its involvement in the remodeling of chromatin structure within IL-4 locus. The expression of GATA-3 itself is regulated by signal transducer and activator of transcription-6 (STAT6).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-GATA-binding factor 3 Antibody, clone 7E8.1 is an antibody against GATA-binding factor 3 for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected GATA-3 in human breast, human skin, and rat kidney tissue sections.
      Biological Information
      ImmunogenGST-tagged recombinant human GATA-binding factor 3 internal fragment.
      EpitopeInternal (N-terminal half).
      Clone7E8.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with both spliced isoforms of human GATA-3 reported by UniProt (P23771).
      IsotypeIgG1κ
      Species Reactivity
      • Human
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GATA3
      • HDR
      • HDRS
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~48 kDa observed. 47.9 kDa (isoform 1) and 48.0 kDa (isoform 2) calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected GATA-3 in 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABE444 04055977314342

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      Categorie

      Life Science Research > Antibodies and Assays > Primary Antibodies