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MABS497 Anti-Cytochrome P450 26B1 Antibody, clone 4B7.2

Anti-Cytochrome P450 26B1 Antibody, clone 4B7.2 is an antibody against Cytochrome P450 26B1 for use in Western Blotting, Immunohistochemistry (Paraffin).

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Research Category: Signaling Research Sub-Category: Toxicology & Drug Resistance Gene Symbol: CYP26B1, CYP26A2, P450RAI2, RHFCA UniProt Number: Q9NR63
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MABS497
100 μg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS497
      DescriptionAnti-Cytochrome P450 26B1 Antibody, clone 4B7.2
      Alternate Names
      • Cytochrome P450 26B1
      • Cytochrome P450 26A2
      • Cytochrome P450 retinoic acid-inactivating 2
      • Cytochrome P450, subfamily XXVIB, polypeptide 1
      • Cytochrome P450RAI-2
      • Retinoic acid-metabolizing cytochrome
      Background InformationCytochrome P450 26B1 (UniProt Q9NR63; also known as Cytochrome P450 26A2, Cytochrome P450 retinoic acid-inactivating 2, Cytochrome P450, subfamily XXVIB, polypeptide 1, Cytochrome P450RAI-2, Retinoic acid-metabolizing cytochrome) is encoded by the CYP26B1 (also known as CYP26A2, P450RAI2, RHFCA) gene (Gene ID 56603) in human. Cytochromes P450 (CYP) proteins are primarily membrane-associated oxidases located either in the inner membrane of mitochondria or in the endoplasmic reticulum. In addition to processing endogenous substrates, CYPs also metabolize exogenous drugs and potentially toxic chemicals. The human CYP superfamily consists of 57 genes and more than 59 pseudogenes divided into 18 families and 43 subfamilies. The CYP26 subfamily of enzymes (CYP26A1, CYP26B1/CYP26A2, CYP26C1) are retinoic acid hydroxylases responsible for the inactivation of all-trans-retinoic acid to hydroxylated forms, such as 4-oxo-, 4-OH-, and 18-OH-all-trans-retinoic acid. CYP26B1 is overexpressed in colorectal cancer (CRC) cells, high CYP26B1 expression level in CRC patients is associated with poor prognosis. CYP26B1 mutations are found in radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA), a disease characterized by craniofacial malformations, occipital encephalocele, radiohumeral fusions, oligodactyly, advanced osseous maturation, and calvarial mineralization defects.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Cytochrome P450 26B1 Antibody, clone 4B7.2 is an antibody against Cytochrome P450 26B1 for use in Western Blotting, Immunohistochemistry (Paraffin).
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected Cytochrome P450 26B1 in human brain, mouse brain, and rat cerebellum tissue.
      Biological Information
      ImmunogenGST-tagged recombinant internal fragment from the C-terminal half of human Cytochrome P450 26B1.
      EpitopeInternal (C-terminal half).
      Clone4B7.2
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityExpected to react with all three spliced isoforms of human CYP26B1 reported by UniProt (Q9NR63).
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CYP26B1
      • CYP26A2
      • P450RAI2
      • RHFCA
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~57 kDa observed. 57.51 kDa (isoform 1), 49.01 kDa (isoform 2), and 55.76 kDa (isoform 3) calculated. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in mouse brain tissue microsomal lysate.

      Western Blotting Analysis: 2.0 µg/mL of this antibody detected Cytochrome P450 26B1 in 10 µg of mouse brain tissue microsomal lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABS497 04055977334395