Millipore Sigma Vibrant Logo

MAB1379 Anti-CD54 Antibody, extracellular, clone 84H10

View Products on Sigmaaldrich.com
MAB1379
100 µg  
Non è stato possibile trovare il prezzo
La quantità minima deve essere un multiplo di
Maximum Quantity is
Al termine dell'ordine Maggiori informazioni
Lei ha salvato ()
 
Richiedi il prezzo
Disponibilità limitata
Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      Offerte speciali

       

      Contatti il Servizio Clienti

      Panoramica

      Offerte speciali

      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IP, IHC, FUNCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1379
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD54 Antibody, extracellular, clone 84H10
      Alternate Names
      • ICAM-1
      Background InformationThis molecule is inducible to high levels by mitogenic lectins on lymphocytes and by IL-1beta or IFN gamma on other cell types such as fibroblasts and enthothelial cells.
      Product Information
      FormatPurified
      PresentationAffinity purified immunoglobulin. Liquid in Phosphate buffered saline, pH 7.4, containing 0.09% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect CD54 using this Anti-CD54 Antibody, extracellular, clone 84H10 validated for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      • Affects Function
      Applications Not Recommended
      • Immunohistochemistry (Paraffin)
      Application NotesFlow Cytometry: Neat - 1:10. 10 μL of suggested dilution will label 10e6 cells.

      Immunohistochemistry on frozen tissue sections: 1:20-1:50. Does not work on paraffin embedded tissue sections.

      Immunoprecipitation: 5 μg/ 10e7 cells

      Adhesion Blocking; blocks ICAM-1 mediated adhesion to LFA-1.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenK562 cell line
      Epitopeextracellular
      Clone84H10
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes the extracellular D1 domain of ICAM-1. Blocks binding of LFA-1 and P. falciparum to ICAM-1. Reacts with the ICAM-1 antigen found in low levels on lymphocytes and strongly expressed on monocytes and granulocytes. Detects an antigen of 90 kDa.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryICAM1 (CD54) is typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. ICAM1 is also exploited by Rhinovirus as a receptor.
      Gene Symbol
      • ICAM1
      • P3.58
      • BB2
      • CD54
      • ICAM-1
      Non-Reactive Species
      • Canine
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P05362 # ICAM proteins are ligands for the leukocyte adhesion protein LFA-1 (integrin alpha-L/beta-2). In case of rhinovirus infection acts as a cellular receptor for the virus. Also acts as receptor for some coxsackieviruses.
      SIZE: 532 amino acids; 57825 Da
      SUBUNIT: Interacts with human herpesvirus 8 MIR2 protein (Probable).
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      PTM: Monoubiquitinated, which is promoted by MARCH9 and leads to endocytosis.
      SIMILARITY: SwissProt: P05362 ## Belongs to the immunoglobulin superfamily. ICAM family. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at 2-8°C for up to 12 months from date of receipt. Alternatively, this antibody can be stored at -20ºC. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Numero di catalogo GTIN
      MAB1379 04053252315978