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04-973 Anti-CD39 Antibody, clone 5F2

This Anti-CD39 Antibody, clone 5F2 is validated for use in FC, WB for the detection of CD39.

Anti-CD39 Antibody, clone 5F2: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Inflammation & Immunology Research Sub-Category: Cytokines & Cytokine Receptors Gene Symbol: CD39, Ecto-apyrase, Ectoapyrase UniProt Number: P55772
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04-973
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue Number04-973
      DescriptionAnti-CD39 Antibody, clone 5F2
      Alternate Names
      • ectonucleoside triphosphate diphosphohydrolase 1
      • ATPDase
      • ecto-apyrase
      • NTPDase-1
      • Ecto-ATP diphosphohydrolase
      • Lymphoid cell activation antigen
      • NTPDase 1
      • Ecto-apyrase
      • CD39 antigen
      Background InformationEctonucleoside triphosphate diphosphohydrolase 1 (NTDase 1 or CD39) belongs to the membrane-bound ecto-nucleoside triphosphates diphosphohydrolase family (E-NTPDases) that are characterized for their ability to hydrolyze nucleoside di- and triphosphates, such as ATP, in the presence of cations, i.e. CA2+ and Mg2+. CD39 is an important membrane protein containing two transmembrane domains and a large NTPDase active, extracellular region containing apyrase conserved regions. It is heavily glycosolated, having six known N-glycosolation sites, and functions on the plasma membrane’s outer surface. CD39 initiates the metabolism, of ATP and ADP to adenosine through a 2-step exzymatic reaction, providing extracellular adenosine for the purpose of regulating various inflammatory endpoints. It is a putative marker for B-cell activation and its expression has also been observed on NK-cells, dendritic cells, T-cells, and vascular endothelial cells. CD39 is a known inhibitor of ADP-induced platelet aggregation and may also play a role in angiogenesis.
      References
      Product Information
      FormatPurified
      Control
      • BALB/c splenocytes
      PresentationPurified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-CD39 Antibody, clone 5F2 is validated for use in FC, WB for the detection of CD39.
      Key Applications
      • Flow Cytometry
      • Western Blotting
      Application NotesWestern Blot Analysis: A previous lot was used by an independent laboratory in WB.
      Biological Information
      ImmunogenRecombinant protein corresponding to mouse CD39.
      EpitopeUnknown
      Clone5F2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityThis antibody recognizes CD39.
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD39
      • Ecto-apyrase
      • Ectoapyrase
      Purification MethodProtein G Purified
      UniProt Number
      UniProt SummaryFUNCTION: In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation. Hydrolyzes ATP and ADP equally well.

      CATALYTIC ACTIVITY: ATP + 2 H2O = AMP + 2 phosphate.

      COFACTOR: Calcium (By similarity).

      MAGNESIUM: (By similarity).

      SUBUNIT STRUCTURE: Homodimer; disulfide-linked (By similarity).

      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).

      SEQUENCE SIMILARITIES: Belongs to the GDA1/CD39 NTPase family.
      Molecular Weight~ 100 kDa.
      It has been published that CD39 shows molecular weights between ~70-100 kDa (Wang, T.F. et al., 1996).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in BALB/c splenocytes.

      Flow Cytometry Analysis: 0.1 µg/mL of this antibody detected CD39 in BALB/c splenocytes.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      04-973 04053252478628

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      Categorie

      Life Science Research > Antibodies and Assays > Primary Antibodies