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ABN30 Anti-Aromatase Antibody

Anti-Aromatase Antibody is an antibody against Aromatase for use in WB.

Anti-Aromatase Antibody: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Neurochemistry & Neurotrophins Gene Symbol: CYP19A1, ARO1, CYAR, CYP19 UniProt Number: P11511
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ABN30
100 µg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, B, Chp, Rhesus Macaque, Po, CaWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN30
      DescriptionAnti-Aromatase Antibody
      Alternate Names
      • Cytochrome P450 19A1
      • Aromatase
      • CYPXIX
      • Cytochrome P-450AROM
      • Estrogen synthase
      Background InformationHuman Aromatase is a membrane-bound enzyme that is localized on the endoplasmic reticulum. While it is found in gonads and adrenal glands where it converts androgens into estrogens in a classical endocrine manner, it is also expressed in various tissues where it regulates local estrogen levels or estrogen/androgen ratios in an intracrine manner. Human Aromatase is known to have two major forms, characterized by one amino acid difference at amino acid position 264 [arginine (264R) and cysteine (264C)]. Abnormal Aromatase hyperactivity is a known cause for Aromatase excess syndrome (AES), which is characterized by excess levels of estrogen, heterosexual precocity in adolescent males and isosexual precocity in adolescent females. On the other hand, Aromatase deficiency (AROD) in Aromatase-deficient (ArKO) mice leads to increased adiposity, an inability to synthesize estrogen, birth defects, and genital-related developmental disorders. It is also reported to play a role in a complex immune-neuro-endocrine network management system in murine cysticercosis.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Human placenta tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Aromatase Antibody is an antibody against Aromatase for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern Blot Analysis: 1 µg/mL from a representative lot detected Aromatase in 10 µg of human testis.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Aromatase.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Bovine
      • Chimpanzee
      • Rhesus Macaque
      • Pig
      • Canine
      Species Reactivity NoteDemonstrated to react with Human. Predicted to react with Bovine, Chimpanzee, Rhesus Macaque, Porcine, and Canine based on 100% sequence homology. Other homolgoies: Rat and Mouse (94% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and catalyzes the last steps of estrogen biosynthesis, three successive hydroxylations of the A ring of androgens. Mutations in this gene can result in either increased or decreased aromatase activity; the associated phenotypes suggest that estrogen functions both as a sex steroid hormone and in growth or differentiation. The gene expresses two transcript variants.
      Gene Symbol
      • CYP19A1
      • ARO1
      • CYAR
      • CYP19
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Catalyzes the formation of aromatic C18 estrogens from C19 androgens.

      CATALYTIC ACTIVITY: RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

      COFACTOR: Heme group.

      SUBCELLULAR LOCATION: Membrane; Peripheral membrane protein.

      TISSUE SPECIFICITY: Brain, placenta and gonads.
      Molecular Weight~58 kDa observed. UniProtKB/Swiss-Prot P11511 (CP19A_HUMAN) states a molecular weight of ~58 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in human placenta tissue lysate.

      Western Blot Analysis: 0.5 µg/mL of this antibody detected Aromatase in 10 µg of human placenta tissue lysate. Tween was not used in the Western Blot.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      ABN30 04053252592034