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MABN466 Anti-Ankyrin-G Antibody, clone N106/36

Anti-Ankyrin-G Antibody, clone N106/36 is a highly specific mouse monoclonal antibody & that targets Ankyrin & has been tested in IHC.

Anti-Ankyrin-G Antibody, clone N106/36: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: ANK3 UniProt Number: Q12955
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MABN466
100 µg  
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      Tabella delle specifiche principali

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RIHCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN466
      DescriptionAnti-Ankyrin-G Antibody, clone N106/36
      Alternate Names
      • Ankyrin-3
      • ANK-3
      • Ankyrin-G
      Background InformationAnkyrins are a family of spectrin-binding proteins that couple the spectrin/actin cytoskeletal network to the cytoplasmic domains of integral membrane proteins which include channels such as the anion exchanger, voltage-dependent sodium channel, and the Na/K ATPase, as well as neuronal cell adhesion molecules related to L1. In the nervous system, three different ankyrins are known to exist; ankyrinB, ankyrinG, and ankyrinR. All three ankyrins contain an N-terminal membrane binding domain, an internal domain capable of binding spectrin, and a C-terminal regulatory domain which is the target of alternative splicing. AnkyrinB, the predominant neuronal ankyrin includes two isoforms of ~220 kDa and ~440 kDa. The ~220 kDa alternatively spliced isoform is the major form present in the adult brain, while the ~440 kDa form is preferentially expressed in the developing neonatal brain. Three forms of ankyrinG (~190 kDa, ~270 kDa, ~480 kDa) are localized in axonal initial segments and the nodes of Ranvier of myelinated axons where fluxes of action potential occur and ion channels are enriched. Ankyrins comprise ~0.5%-1% of the total membrane protein in the adult vertebrate brain.
      References
      Product Information
      FormatPurified
      Control
      • Rat hippocampus tissue
      PresentationPurified mouse monoclonal IgG2aκ in 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Ankyrin-G Antibody, clone N106/36 is a highly specific mouse monoclonal antibody & that targets Ankyrin & has been tested in IHC.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Ankyrin-G in rat cerebral cortex tissue.

      Immunohistochemistry Analysis: A representative lot detected Ankyrin-G in rat optic nerve tissue.

      Immunofluorescence Analysis: A representative lot detected Ankyrin-G in adult rat cortex tissue.

      Immunofluorescence Analysis: A representative lot from an independent laboratory detected Ankyrin-G in a rat model of TLE mEC layer II neurons (Hargus, N. J., et al. (2011). Neurobiol Dis. 41(2):361-376.)
      Biological Information
      ImmunogenRecombinant protein corresponding to human Ankyrin-G.
      CloneN106/36
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Rat
      Species Reactivity NoteDemonstrated to react with Rat. Other homologies: Human (92% sequence homology), and Mouse (87% sequence homology).
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • ANK3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight480 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in rat hippocampus tissue.

      Immunohistochemistry Analysis: A 1:500 dilution from a representative lot detected Ankyrin-G in rat hippocampus tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      MABN466 04053252830587

      Documentation

      Anti-Ankyrin-G Antibody, clone N106/36 MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Anti-Ankyrin-G Antibody, clone N106/36 Certificati d'Analisi

      TitoloNumero di lotto
      Anti-Ankyrin-G, clone N106/36 - 2952322 2952322
      Anti-Ankyrin-G, clone N106/36 - 3213939 3213939
      Anti-Ankyrin-G, clone N106/36 - 3307318 3307318
      Anti-Ankyrin-G, clone N106/36 - 3324989 3324989
      Anti-Ankyrin-G, clone N106/36 - 3462114 3462114
      Anti-Ankyrin-G, clone N106/36 - 3503449 3503449
      Anti-Ankyrin-G, clone N106/36 - 3681275 3681275
      Anti-Ankyrin-G, clone N106/36 - 3743894 3743894
      Anti-Ankyrin-G, clone N106/36 - 3868387 3868387
      Anti-Ankyrin-G, clone N106/36 - 3879505 3879505
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