Millipore Sigma Vibrant Logo

532996 Androgen Receptor DBD Inhibitor, VPC-14449 - CAS 1621375-32-3 - Calbiochem

VPC-14449, is a cell-permeable compound that selectively binds to the DNA-binding domain of androgen receptor (AR) and blocks its activity (IC₅₀ = 340 nM in PC3 cells).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: AR-DBD Inhibitor, VPC-14449, VPC14449, VPC 14449

Primary Target: Androgen Receptor
View Products on Sigmaaldrich.com
532996
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
1621375-32-3C₁₀H₁₀Br₂N₄OS

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
5329960001
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Bottiglia di vetro 10 mg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewA cell-permeable morpholinyl thiazole compound that selectively binds to the DNA-binding domain of androgen receptor (AR) and blocks its activity (IC50 = 340 nM in PC3 cells). Its inhibitory effect is comparable to enzalutamide (IC50 = 314 nM). Does not affect Y594D and Q592D mutant forms of AR. However, Y594A and Q592A mutant AR activity can be inhibited at much higher concentrations (3 - 6 mM). Shown to down-regulate the expression of AR-responsive genes in LNCaP Cells, however, it does not affect genotoxin-responsive genes expression. Suppresses the growth of androgen-sensitive LNCaP xenografts in mice (~100 mg/kg, i.p., b.i.d.).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number532996
      Brand Family Calbiochem®
      SynonymsAR-DBD Inhibitor, VPC-14449, VPC14449, VPC 14449
      References
      ReferencesDalal, K., et al. 2014. J. Biol. Chem. 289, 26417.
      Product Information
      CAS number1621375-32-3
      FormOff-white solid
      Hill FormulaC₁₀H₁₀Br₂N₄OS
      Chemical formulaC₁₀H₁₀Br₂N₄OS
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetAndrogen Receptor
      Primary Target IC<sub>50</sub>947 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      5329960001 04055977282009

      Documentation

      Androgen Receptor DBD Inhibitor, VPC-14449 - CAS 1621375-32-3 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Androgen Receptor DBD Inhibitor, VPC-14449 - CAS 1621375-32-3 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      532996

      Riferimenti bibliografici

      Panoramica delle referenze
      Dalal, K., et al. 2014. J. Biol. Chem. 289, 26417.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-November-2015 JSW
      SynonymsAR-DBD Inhibitor, VPC-14449, VPC14449, VPC 14449
      DescriptionA cell-permeable morpholinyl thiazole compound that selectively binds to the DNA-binding domain of androgen receptor (AR) and blocks its activity (IC50 = 340 nM in PC3 cells). Its inhibitory effect is comparable to enzalutamide (IC50 = 314 nM). Does not affect Y594D and Q592D mutant forms of AR. However, Y594A and Q592A mutant AR activity can be inhibited at much higher concentrations (3 - 6 mM). Shown to down-regulate the expression of AR-responsive genes in LNCaP Cells, however, it does not affect genotoxin-responsive genes expression. Suppresses the growth of androgen-sensitive LNCaP xenografts in mice (~100 mg/kg, i.p., b.i.d.).

      Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1621375-32-3
      Chemical formulaC₁₀H₁₀Br₂N₄OS
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDalal, K., et al. 2014. J. Biol. Chem. 289, 26417.