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129876 Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem

An inhibitor of angiogenesis.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Acid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I

Primary Target: capillary morphogenesis
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129876
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
2016-88-8C₆H₈ClN₇O • HCl

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Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
129876-100MG
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      Description
      OverviewAn inhibitor of angiogenesis. Inhibits capillary morphogenesis completely and reversibly at approximately 130 µM. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+,K+-ATPase. Also acts as an inhibitor of urokinase-type plasminogen activator (uPA). Blocks smooth muscle responses to contractile stimuli and palytoxin-induced conductance in skeletal muscle. Reduces electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
      Catalogue Number129876
      Brand Family Calbiochem®
      SynonymsAcid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
      References
      ReferencesKnoll, A., et al. 1999. Microvasc. Res. 58, 1.
      Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
      Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
      Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
      Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
      Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
      Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.
      Product Information
      CAS number2016-88-8
      ATP CompetitiveN
      FormOff-white to yellow solid
      Hill FormulaC₆H₈ClN₇O • HCl
      Chemical formulaC₆H₈ClN₇O • HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcapillary morphogenesis
      Primary Target IC<sub>50</sub>130 µM inhibiting capillary morphogenesis completely and reversibly
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUQ2275500
      Safety Information
      R PhraseR: 25

      Toxic if swallowed.
      S PhraseS: 45-36

      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      129876-100MG 04055977222289

      Documentation

      Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Amiloride, Hydrochloride - CAS 2016-88-8 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      129876

      Riferimenti bibliografici

      Panoramica delle referenze
      Knoll, A., et al. 1999. Microvasc. Res. 58, 1.
      Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
      Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
      Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
      Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
      Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
      Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-April-2009 JSW
      SynonymsAcid-Sensing Ion Channel Modulator I, ASIC Channel Modulator I
      DescriptionAn inhibitor of angiogenesis. At low concentrations, acts as a potent and specific inhibitor of transmembrane Na+ entry and Na+/H+ ATPase. Inhibits smooth muscle responses to contractile stimuli. Blocks palytoxin-induced conductance in skeletal muscle. Reduces the electrical potential across tubular epithelium. At higher concentrations, blocks the Na+/H+ exchange pathway.
      FormOff-white to yellow solid
      CAS number2016-88-8
      RTECSUQ2275500
      Chemical formulaC₆H₈ClN₇O • HCl
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (5 mg/ml) or H₂O (2.5 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Aqueous stock solutions are stable for up to 6 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 406
      ReferencesKnoll, A., et al. 1999. Microvasc. Res. 58, 1.
      Swiercz, R., et al. 1999. Oncol. Rep. 6, 523.
      Moran, A., et al. 1995. Am. J. Physiol. 268, C350.
      Alliegro, M.C., et al. 1993. J. Exp. Zool. 267, 245.
      Sugiyama, S., et al. 1988. J. Biol. Chem. 263, 8215.
      Yoshida, K., et al. 1988. Biochem. Biophys. Res. Commun. 154, 101.
      Sariban-Sotorabay, S., and Benos, D.J. 1986. Am. J. Physiol. 250, C175.