Millipore Sigma Vibrant Logo

126855 Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate

Primary Target: Farnesyl diphosphate synthase
View Products on Sigmaaldrich.com
126855
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
121268-17-5C₄H₁₂NNaO₇P₂ • 3H₂O

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
126855-100MG
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Fiala di plastica 100 mg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
      Catalogue Number126855
      Brand Family Calbiochem®
      SynonymsAlendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
      References
      ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.
      Product Information
      CAS number121268-17-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄H₁₂NNaO₇P₂ • 3H₂O
      Chemical formulaC₄H₁₂NNaO₇P₂ • 3H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFarnesyl diphosphate synthase
      Primary Target IC<sub>50</sub>460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells
      Purity≥98% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSSZ6523500
      Safety Information
      R PhraseR: 22;
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      126855-100MG 04055977222142

      Documentation

      Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      126855

      Riferimenti bibliografici

      Panoramica delle referenze
      Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-April-2008 RFH
      SynonymsAlendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
      DescriptionAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC50 = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC50 = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC50 = 40-70 µM).
      FormWhite solid
      CAS number121268-17-5
      RTECSSZ6523500
      Chemical formulaC₄H₁₂NNaO₇P₂ • 3H₂O
      Structure formulaStructure formula
      Purity≥98% by titration
      SolubilityH₂O (10 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 229
      ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.