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182690 AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem

The AhR Agonist V, VAF347 controls the biological activity of AhR. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: (4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine

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182690
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182690-10MG
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      Description
      OverviewA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
      Catalogue Number182690
      Brand Family Calbiochem®
      Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
      References
      ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
      Hauben, E., et al. 2008. Blood 118, 1214.
      Lawrence, B.P., et al. 2008. Blood 112, 1158.
      Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
      Product Information
      CAS number574759-62-9
      FormWhite solid
      Hill FormulaC₁₇H₁₁ClF₃N₃
      Chemical formulaC₁₇H₁₁ClF₃N₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      182690-10MG 04055977204445

      Documentation

      AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      AhR Agonist V, VAF347 - CAS 574759-62-9 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      182690

      Riferimenti bibliografici

      Panoramica delle referenze
      Platzer, B., et al. 2009. J. Immunol. 183, 66.
      Hauben, E., et al. 2008. Blood 118, 1214.
      Lawrence, B.P., et al. 2008. Blood 112, 1158.
      Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-August-2012 JSW
      Synonyms(4-(3-Chloro-phenyl)-pyrimidin-2-yl)-(4-trifluoromethyl-phenyl)-amine
      DescriptionA cell-permeable pyrimidinylphenylamine compound that directly and reversibly targets aryl hydrocarbon receptor (AhR) with high-affinity, and induces AhR signaling. Reported to act as an immunomodulator with anti-inflammatory properties. Potently suppresses IgE secretion in B-cells with an IC50 of ~2 nM, and inhibits dendritic cells-mediated T-cell proliferation and cytokine production. Further, decreases lung eosinophilia in B-cell-deficient mice, and allergic inflammation. Downregulates PU.1 transcription factor, and impairs human monocytes and Langerhans dendritic cells differentiation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number574759-62-9
      Chemical formulaC₁₇H₁₁ClF₃N₃
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesPlatzer, B., et al. 2009. J. Immunol. 183, 66.
      Hauben, E., et al. 2008. Blood 118, 1214.
      Lawrence, B.P., et al. 2008. Blood 112, 1158.
      Ettmayer, P., et al. 2006. Am. J. Respir. Crit. Care Med. 173, 599.