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116814 Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt - CAS 151837-09-1 - Calbiochem

A cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: Adenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Rp, Rp-cAMPS, TEA, PKA Inhibitor V

Primary Target: PKA
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116814
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
151837-09-1C₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH

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      Description
      OverviewA cell-permeable and reversible inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Noncompetitive with respect to ATP.
      Note: 5 µmol = 2.23 mg.
      Catalogue Number116814
      Brand Family Calbiochem®
      SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Rp, Rp-cAMPS, TEA, PKA Inhibitor V
      References
      ReferencesKaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
      Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys. 420, 336.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Butt, E., et al. 1990. FEBS Lett. 263, 47.
      Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
      Rothermel, J.D. 1988. Biochem. J. 251, 757.
      Eckstein, F. 1985. Annu. Rev. Biochem. 54, 367.
      de Wit, R.J., et al. 1984. Eur. J. Biochem. 142, 255.
      O'Brian, C.A., et al. 1982. Biochemistry 21, 4371.
      Product Information
      CAS number151837-09-1
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
      Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKA
      Primary Target K<sub>i</sub>11 µM against protein kinase A
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      116814-5UMOL 07790788047825

      Documentation

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt - CAS 151837-09-1 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      Adenosine 3ʹ,5ʹ-cyclic Monophosphorothioate, Rp-Isomer, Triethylammonium Salt - CAS 151837-09-1 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      116814

      Riferimenti bibliografici

      Panoramica delle referenze
      Kaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
      Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys. 420, 336.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Butt, E., et al. 1990. FEBS Lett. 263, 47.
      Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
      Rothermel, J.D. 1988. Biochem. J. 251, 757.
      Eckstein, F. 1985. Annu. Rev. Biochem. 54, 367.
      de Wit, R.J., et al. 1984. Eur. J. Biochem. 142, 255.
      O'Brian, C.A., et al. 1982. Biochemistry 21, 4371.

      Brochure

      Titolo
      Inhibitor Sourcebook 3rd Edition
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-September-2007 RFH
      SynonymsAdenosine 3ʹ,5ʹ-cyclic Phosphorothioate-Rp, Rp-cAMPS, TEA, PKA Inhibitor V
      DescriptionCell permeable inhibitor of protein kinase A (Ki = 11 µM). Resistant to hydrolysis by phosphodiesterases. Note: 5 µmol = 2.23 mg
      FormCrystalline solid
      CAS number151837-09-1
      Chemical formulaC₁₀H₁₁N₅O₅PS · (CH₃CH₂)₃NH
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (20 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKaji, H., et al. 1992. Biochem. Biophys. Res. Commun. 182, 1356.
      Van der Kloot, W., and Branisteanu, D.D. 1992. Eur. J. Phys. 420, 336.
      Yokozaki, H., et al. 1992. Cancer Res. 52, 2504.
      Butt, E., et al. 1990. FEBS Lett. 263, 47.
      Dostmann, W.R., et al. 1990. J. Biol. Chem. 265, 10484.
      Rothermel, J.D. 1988. Biochem. J. 251, 757.
      Eckstein, F. 1985. Annu. Rev. Biochem. 54, 367.
      de Wit, R.J., et al. 1984. Eur. J. Biochem. 142, 255.
      O'Brian, C.A., et al. 1982. Biochemistry 21, 4371.