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288104 2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem

Cell-permeable, non-competitive adenylate cyclase inhibitor (IC₅₀ = 3 µM), that binds to the adenosine P1 binding site.

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 2ʹ,5ʹ-dd-Ado

Primary Target: adenylate cyclase
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288104
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Tabella delle specifiche principali

CAS #Empirical Formula
6698-26-6C₁₀H₁₃N₅O₂

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
288104-1MG
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      Description
      OverviewCell-permeable, non-competitive adenylate cyclase inhibitor (IC50 = 3 µM), that binds to the adenosine P1 binding site. Blocks positive inotropic and chronotropic effects of β-adrenergic agents.
      Catalogue Number288104
      Brand Family Calbiochem®
      Synonyms2ʹ,5ʹ-dd-Ado
      References
      ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
      Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
      Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
      Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
      Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
      Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
      Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.
      Product Information
      CAS number6698-26-6
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₀H₁₃N₅O₂
      Chemical formulaC₁₀H₁₃N₅O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetadenylate cyclase
      Primary Target IC<sub>50</sub>3 µM against adenylate cyclase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      288104-1MG 04055977197914

      Documentation

      2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem MSDS

      Titolo

      Scheda di sicurezza (MSDS) 

      2ʹ,5ʹ-Dideoxyadenosine - CAS 6698-26-6 - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      288104

      Riferimenti bibliografici

      Panoramica delle referenze
      Ibrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
      Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
      Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
      Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
      Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
      Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
      Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.

      Brochure

      Titolo
      Activators and Inhibitors of Adenylate Cyclase Technical Bulletin
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-June-2008 RFH
      Synonyms2ʹ,5ʹ-dd-Ado
      DescriptionMembrane-permeable adenylate cyclase inhibitor that binds non-competitively to the enzyme via the P-site. Its inhibitory effect varies widely among tissues (IC50 = 3 µM for detergent solubilized rat brain membranes; IC50 = 45 µM for purified bovine brain enzyme). Blocks the forskolin-induced activation of adenylate cyclase activity (IC50 = 540 µM) in cultured bovine aortic endothelial cells. Also blocks the positive ionotropic and chronotropic effects of β-adrenergic agents.
      FormWhite solid
      CAS number6698-26-6
      Chemical formulaC₁₀H₁₃N₅O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesIbrahimi, A., et al. 1999. Am. J. Physiol. 276, C487.
      Hartman, M., and Schrader, J. 1995. J. Mol. Cell. Cardiol. 25, 331.
      Bushfield, M., et al. 1990. Mol. Pharmacol. 38, 848.
      Reid, I.R., et al. 1990. Am. J. Physiol. 258, E708.
      Legrand, A.B., et al. 1990. Biochem. Pharmacol. 40, 1103.
      Johnson, R.A., et al. 1989. Mol. Pharmacol. 35, 681.
      Holgate, S.T., et al. 1980. Proc. Natl. Acad. Sci. USA 77, 6800.