Millipore Sigma Vibrant Logo

565781 β-Secretase Substrate VI, Fluorogenic - Calbiochem

A highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ~4.0, kcat = 0.02 sec⁻¹; Km = 9 µM).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: H-K(DABSYL)-SEVNLDAEFRQ(LY)

565781
Visualizza prezzi e disponibilità

Panoramica

Replacement Information

Prezzi e disponibilità

Numero di catalogo DisponibilitàConfezionamento Qtà/conf Prezzo Quantità
565781-500UG
Verifica della disponibilità in corso...
—
Disponibilità limitata Disponibilità limitata
A magazzino 
Fuori produzione
Disponibili quantità limitate
La disponibilità deve essere confermata
    Prodotti rimanenti: riceverà un nostro avviso
      Prodotti rimanenti: riceverà un nostro avviso
      Will advise
      Contatti il Servizio Clienti
      Contact Customer Service

      		 Fiala di plastica 500 μg
      Ricerca del prezzo in corso...
      Non è stato possibile trovare il prezzo
      La quantità minima deve essere un multiplo di
      Maximum Quantity is
      Al termine dell'ordine Maggiori informazioni
      Lei ha salvato ()
       
      —
      Richiedi il prezzo
      		 —
      Description
      OverviewA highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE); (pH ~4.0, kcat = 0.02 sec-1; Km = 9 µM). Derived from the Swedish mutant APP (amyloid precursor protein) β-cleavage site (-NL↓DA-). Useful for high throughput screening of β-secretase inhibitors.
      Catalogue Number565781
      Brand Family Calbiochem®
      SynonymsH-K(DABSYL)-SEVNLDAEFRQ(LY)
      References
      ReferencesGrüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.
      Product Information
      ATP CompetitiveN
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Hill FormulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Chemical formulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE)
      Primary Target IC<sub>50</sub>kcat = 0.02 sec⁻¹ and Km = 9 µM at pH ~4.0 as fluorescence resonance energy transfer (FRET) peptide substrate for β-secretase (BACE)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Emission max.
      Excitation max.
      Peptide SequenceH-Lys(DABSYL)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gin-(LY)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Numero di catalogo GTIN
      565781-500UG 04055977267297

      Documentation

      β-Secretase Substrate VI, Fluorogenic - Calbiochem Certificati d'Analisi

      TitoloNumero di lotto
      565781

      Riferimenti bibliografici

      Panoramica delle referenze
      Grüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.
      Scheda tecnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsH-K(DABSYL)-SEVNLDAEFRQ(LY)
      DescriptionA highly selective, fluorescence resonance energy transfer (FRET) peptide substrate for b-secretase (BACE) (pH ~4.0, kcat = 0.02 sec-1; Km = 9 µM). Derived from the Swedish mutant APP (amyloid precursor protein) β-cleavage site (-NL ↓ DA-). Useful for high throughput screening of β-secretase inhibitors. Excitation max.: ~430 nm; emission max.: ~520 nm.
      FormLyophilized solid
      FormulationSupplied as a trifluoroacetate salt.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₈₉H₁₂₂N₂₄O₃₁S₃
      Peptide SequenceH-Lys(DABSYL)-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Gin-(LY)
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesGrüninger-Leitch, F., et al. 2002. J. Biol. Chem. 277, 4687.