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487910 (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem

Nitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC₅₀ = 130 nM).

MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: SNAP

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487910
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Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
79032-48-7C₇H₁₂N₂O₄S

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      487910-20MG
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          Description
          OverviewNitric oxide donor that mimics the actions of nitric oxide, including relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
          Catalogue Number487910
          Brand Family Calbiochem®
          SynonymsSNAP
          References
          ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
          Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
          Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
          Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
          Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
          Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
          Product Information
          CAS number79032-48-7
          ATP CompetitiveN
          FormPale green solid
          Hill FormulaC₇H₁₂N₂O₄S
          Chemical formulaC₇H₁₂N₂O₄S
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetNitric oxide donor
          Primary Target IC<sub>50</sub>EC50 = 130 nM in relaxation of isolated bovine coronary artery rings
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableN
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 36/37/38

          Irritating to eyes, respiratory system and skin.
          S PhraseS: 26-36

          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing.
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Irritant
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
          Packaging Information
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Numero di catalogo GTIN
          487910-1SET 04055977200324
          487910-20MG 04055977200331

          Documentation

          (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem MSDS

          Titolo

          Scheda di sicurezza (MSDS) 

          (±)-S-Nitroso-N-acetylpenicillamine - CAS 79032-48-7 - Calbiochem Certificati d'Analisi

          TitoloNumero di lotto
          487910

          Riferimenti bibliografici

          Panoramica delle referenze
          Nishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
          Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
          Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
          Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
          Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
          Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.

          Brochure

          Titolo
          Caspases and other Apoptosis Related Tools Brochure

          Citazioni

          Titolo
        • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
          		•
          Scheda tecnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision25-October-2016 JSW
          SynonymsSNAP
          DescriptionNitric oxide donor that begins to evolve nitric oxide immediately upon solubilization in aqueous buffers (t1/2 = 10 h). Mimics the actions of nitric oxide, including the relaxation of isolated bovine coronary artery rings (EC50 = 130 nM). Markedly activates soluble guanylate cyclase. Also reported to cause the reversible inactivation of protein kinase C activity. Induces apoptosis in mouse thymocytes. Note: 1 set = 4 x 5 mg.
          FormPale green solid
          CAS number79032-48-7
          Chemical formulaC₇H₁₂N₂O₄S
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (25 mg/ml), Ethanol (25 mg/ml), or Methanol
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsSNAP evolves NO immediately upon solubilization; reconstitute just prior to use.
          Toxicity Irritant
          ReferencesNishio, E., et al. 1996. Biochem. Biophys. Res. Commun. 221, 163.
          Askew, S.C., et al. 1995. Bioorg. Med. Chem. 3, 1.
          Fehsel, K., et al. 1995. J. Immunol. 155, 2858.
          Gopalkrishna, R., et al. 1993. J. Biol. Chem. 268, 27180.
          Southan, E., and Garthwaite, J. 1991. Neurosci. Lett. 130, 107.
          Henry, P.J., et al. 1989. J. Pharmacol. Exp. Ther. 248, 762.
          Citation
        • Bysani Chandrasekar, et al. (2005) The pro-atherogenic cytokine interleukin-18 induces CXCL16 expression in rat aortic smooth muscle cells via MyD88, interleukin-1 receptor-associated kinase, tumor necrosis factor receptor-associated factor 6, c-Src, phosphatidylinositol 3-kinase, Akt, c-J. Journal of Biological Chemistry 280, 26263-26277.
          		•