324517 Sigma-AldricheIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation.
More>> eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 315706-13-9 | C₁₈H₁₂Cl₂N₄O₄S |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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| 324517-10MG |
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Ampoule plast. | 10 mg |
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| Description | |
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| Overview | A cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519). |
| Catalogue Number | 324517 |
| Brand Family | Calbiochem® |
| Synonyms | 2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I |
| References | |
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| References | Moerke, N. J., et al. 2007. Cell 128, 257. |
| Product Information | |
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| CAS number | 315706-13-9 |
| Form | Yellow solid |
| Hill Formula | C₁₈H₁₂Cl₂N₄O₄S |
| Chemical formula | C₁₈H₁₂Cl₂N₄O₄S |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications | |
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| Application | eIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation. |
| Biological Information | |
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| Purity | ≥98% by HPLC (sum of two isomers) |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 324517-10MG | 04055977197327 |
Documentation
eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem FDS
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eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 324517 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Moerke, N. J., et al. 2007. Cell 128, 257. |
Citations
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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