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692000 ZM 336372 - CAS 208260-29-1 - Calbiochem

A potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC₅₀ = 70 nM).

ZM 336372 - CAS 208260-29-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide

Primary Target: Protein kinase c-Raf
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692000
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
208260-29-1C₂₃H₂₃N₃O₃

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      Description
      OverviewA potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of the protein kinase c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold increased potency compared to B-Raf, but does not inhibit many other protein kinases (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM). The inhibition of c-Raf by ZM 336372 is competitive with respect to ATP.
      Catalogue Number692000
      Brand Family Calbiochem®
      SynonymsN-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
      References
      ReferencesHall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.
      Product Information
      CAS number208260-29-1
      ATP CompetitiveY
      DeclarationSold under license of PCT Application W098/22,103.
      FormOff-white solid
      Hill FormulaC₂₃H₂₃N₃O₃
      Chemical formulaC₂₃H₂₃N₃O₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetProtein kinase c-Raf
      Primary Target IC<sub>50</sub>70 nM against protein kinase c-Raf
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      692000-1MG 04055977274561

      Documentation

      ZM 336372 - CAS 208260-29-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      ZM 336372 - CAS 208260-29-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      692000

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.

      Posters

      Titre
      Human Kinome & InhibitorSelect™ Libraries
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-January-2010 RFH
      SynonymsN-[5-(3-Dimethylaminobenzamido)-2-methylphenyl]-4-hydroxybenzamide
      DescriptionA potent, cell-permeable, reversible, ATP-competitive and specific inhibitor of c-Raf (IC50 = 70 nM). Inhibits c-Raf with ten-fold greater potency compared to B-Raf. Has no significant effect on many other protein kinases tested (even at 50 µM) with the exception of SAPK2a/p38α (IC50 = 2 µM) and SAPK2b/p38β2 (IC50 = 2 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number208260-29-1
      Chemical formulaC₂₃H₂₃N₃O₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHall-Jackson, C.A., et al. 1999. Chem. Biol. 6, 559.