Millipore Sigma Vibrant Logo

681685 WP1130 - CAS 856243-80-6 - Calbiochem

A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway.

WP1130 - CAS 856243-80-6 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Degrasyn

View Products on Sigmaaldrich.com
681685
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
856243-80-6C₁₉H₁₈BrN₃O

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
681685-10MG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Flacon en verre 10 mg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewA cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-κB activities (IC50 < 1 µM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2 µM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5 µM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 (Cat. No. 573097) in xenograft mouse models of CML and melanoma.
      Catalogue Number681685
      Brand Family Calbiochem®
      SynonymsDegrasyn
      References
      ReferencesKapuria, V., et al. 2010. Cancer Res. 70, 9265.
      Pham, L.V., et al. 2010. Mol. Cancer Ther. 9, 2026.
      Bartholomeusz, G.A, et al. 2007. Cancer Res. 67, 3912.
      Bartholomeusz, G.A, et al. 2007. Blood 109, 3470.
      Product Information
      CAS number856243-80-6
      FormLight yellow solid
      Hill FormulaC₁₉H₁₈BrN₃O
      Chemical formulaC₁₉H₁₈BrN₃O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      681685-10MG 04055977225273

      Documentation

      WP1130 - CAS 856243-80-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      WP1130 - CAS 856243-80-6 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      681685

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kapuria, V., et al. 2010. Cancer Res. 70, 9265.
      Pham, L.V., et al. 2010. Mol. Cancer Ther. 9, 2026.
      Bartholomeusz, G.A, et al. 2007. Cancer Res. 67, 3912.
      Bartholomeusz, G.A, et al. 2007. Blood 109, 3470.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision02-April-2012 JSW
      SynonymsDegrasyn
      DescriptionA cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-κB activities (IC50 < 1 µM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2 µM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5 µM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 (Cat. No. 573097) in xenograft mouse models of CML and melanoma.
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number856243-80-6
      Chemical formulaC₁₉H₁₈BrN₃O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesKapuria, V., et al. 2010. Cancer Res. 70, 9265.
      Pham, L.V., et al. 2010. Mol. Cancer Ther. 9, 2026.
      Bartholomeusz, G.A, et al. 2007. Cancer Res. 67, 3912.
      Bartholomeusz, G.A, et al. 2007. Blood 109, 3470.