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533574 TRPML3 Activator, ML123 - CAS 384352-24-3 - Calbiochem

A highly selective agonist of TRPML3 channel (EC₅₀ = 873 nM)

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984

Primary Target: TRPML3
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533574
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Tableau de caractéristiques principal

CAS #Empirical Formula
384352-24-3C₁₆H₂₃ClN₂O₃S

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      Description
      OverviewA non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
      Catalogue Number533574
      Brand Family Calbiochem®
      Synonyms4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
      References
      ReferencesAntolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
      Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
      Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
      Grimm, C., et al. 2010. Chem. Biol. 17, 135.
      Product Information
      CAS number384352-24-3
      FormOff-white solid
      Hill FormulaC₁₆H₂₃ClN₂O₃S
      Chemical formulaC₁₆H₂₃ClN₂O₃S
      ReversibleY
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTRPML3
      Purity≥92% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5335740001 04055977287011

      Documentation

      TRPML3 Activator, ML123 - CAS 384352-24-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Antolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
      Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
      Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
      Grimm, C., et al. 2010. Chem. Biol. 17, 135.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision23-July-2016 JSW
      Synonyms4-Chloro-N-(2-morpholinocyclohexyl)benzenesulfonamide, SF-21, CID2911646, ML123, ML 123, Transient Receptor Potential Channel 3 Activator, SID24801657, Racemate, SR-1984
      DescriptionA non-cytotoxic morpholinyl-cyclohexylbenzenesulfonamide compound that acts as a selective agonist of TRPML3 channel (EC50 = 873 nM in hTRPML3-YPF transfected HEK293 cells). Displays significantly weaker agonistic activity for TRPML2 channel (54.5% at 10 µM) and is shown to be inactive against hTRPML1, hTRPM2, mTRPV2, hTRPC3, drTRPN1, and hTRPA1 (~10 µM). Also binds to sigma-1 receptor at much higher concentrations (IC50 = 31 µM).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number384352-24-3
      Chemical formulaC₁₆H₂₃ClN₂O₃S
      Purity≥92% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAntolin, A.A., and Mestres, J. 2015. ACS Chem. Biol. 10, 395.
      Grimm, C., et al. 2012. J. Biol. Chem. 287, 22701.
      Saldanha, S., et al. 2010. Probe Reports from the NIH Molecular Libraries Program.
      Grimm, C., et al. 2010. Chem. Biol. 17, 135.