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616452 TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

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CAS #Empirical Formula
446859-33-2C₁₇H₁₃N₅

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616452-2MG
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      Description
      OverviewA cell-permeable naphthyridinyl pyrazolo compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK at IC50 > 16 µM. Also available as a 50 mM solution in DMSO (Cat. No. 508158).
      Catalogue Number616452
      Brand Family Calbiochem®
      SynonymsALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
      References
      ReferencesGellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Ichida, J. K., et al. 2009. 5, 491.
      Product Information
      CAS number446859-33-2
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₁₇H₁₃N₅
      Chemical formulaC₁₇H₁₃N₅
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetALKS binding
      Primary Target IC<sub>50</sub>23 nM
      Secondary targetALK 5 auto phosphorylation (IC₅₀ = 4 nM)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      616452-2MG 04055977185829

      Documentation

      TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      616452

      Références bibliographiques

      Aperçu de la référence bibliographique
      Gellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Ichida, J. K., et al. 2009. 5, 491.

      Fiche technique

      Titre
      Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation

      Citations

      Titre
      Maherali N., and Hochedlinger, K., 2009. Current Biology 19, 1718.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      SynonymsALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine
      DescriptionA cell-permeable, potent, selective, reversible, and ATP-competitive inhibitor of TGF-β type I receptor (ALK5; IC50 = 23 nM, 4 nM and 18 nM for ALK5 binding, ALK5 auto-phosphorylation, and TGF-β cellular assay in HepG2 cells, respectively). Minimally affects a panel of 9 closely related kinases including p38 MAPK (IC50 >16 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number446859-33-2
      Chemical formulaC₁₇H₁₃N₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesGellibert, F., et al. 2004. J. Med. Chem. 47, 4494.
      Ichida, J. K., et al. 2009. 5, 491.
      CitationMaherali N., and Hochedlinger, K., 2009. Current Biology 19, 1718.