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574775 Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem

Reversible active-site inhibitor of lysosomal α-mannosidase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol

Primary Target: Lysosomal α-mannosidase
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574775
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Tableau de caractéristiques principal

CAS #Empirical Formula
72741-87-8C₈H₁₅NO₃

Prix & Disponibilité

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574775-500UG
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      		 Ampoule plast. 500 μg
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      Description
      OverviewReversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
      Catalogue Number574775
      Brand Family Calbiochem®
      Synonyms(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
      References
      ReferencesMochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
      Elbein, A.D. 1983. Methods Enzymol. 98, 135.
      Product Information
      CAS number72741-87-8
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₈H₁₅NO₃
      Chemical formulaC₈H₁₅NO₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetLysosomal α-mannosidase
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 20/21/22

      Harmful by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      574775-500UG 04055977189711

      Documentation

      Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Swainsonine, Swainsona canescens - CAS 72741-87-8 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      574775

      Références bibliographiques

      Aperçu de la référence bibliographique
      Mochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
      Elbein, A.D. 1983. Methods Enzymol. 98, 135.

      Citations

      Titre
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2008 RFH
      Synonyms(1S,2S,8R,8aR)-Trihydroxyindolizidine, 8aβ-Indolizidine-1α,2α,8β-triol
      DescriptionReversible active-site inhibitor of lysosomal α-mannosidase. Inhibits the growth of tumors and prevents metastasis in murine models. Blocks the processing of high mannose to complex type oligosaccharides.
      FormWhite solid
      CAS number72741-87-8
      Chemical formulaC₈H₁₅NO₃
      Structure formulaStructure formula
      Purity≥98% by TLC
      SolubilityDMSO (5 mg/ml), H₂O (1 mg/ml), or Chloroform
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Harmful
      ReferencesMochizuki, H., et al. 1993. J. Biol. Chem. 268, 9143.
      Elbein, A.D. 1983. Methods Enzymol. 98, 135.
      Citation
    • Jenny J.L. Ho, et al. (2003) N-glycosylation is required for the surface localization of MUC17 mucin. 23, 585-592.
      		•