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565850 Shikonin - CAS 517-89-5 - Calbiochem

A naphthoquinone found in the Chinese herb Shiunko.

Shikonin - CAS 517-89-5 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Pyruvate Kinase Inhibitor II

Primary Target: TNF-α-induced and B-16 melanoma-induced angiogenesis
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565850
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Tableau de caractéristiques principal

CAS #Empirical Formula
517-89-5C₁₆H₁₆O₅

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565850-10MG
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      		 Ampoule plast. 10 mg
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      Description
      OverviewA naphthoquinone found in the Chinese herb Shiunko. Possesses significant antibacterial, anti-inflammatory, and antitumor activities. Inhibits TNF-α-induced and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αvβ3 and inhibits endothelial cell proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line.
      Catalogue Number565850
      Brand Family Calbiochem®
      SynonymsPyruvate Kinase Inhibitor II
      References
      ReferencesChen, J., et al. 2011. Oncogene 30, 4297.
      Li, H., et al. 1999. Phytother. Res. 13, 236.
      Yoon, Y., et al. 1999. Planta Med. 65, 532.
      Hisa, T., et al. 1998. Anticancer Res. 18, 783.
      Product Information
      CAS number517-89-5
      ATP CompetitiveN
      FormRed solid
      Hill FormulaC₁₆H₁₆O₅
      Chemical formulaC₁₆H₁₆O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α-induced and B-16 melanoma-induced angiogenesis
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSQL8000200
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      565850-10MG 04055977191943

      Documentation

      Shikonin - CAS 517-89-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Shikonin - CAS 517-89-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      565850

      Références bibliographiques

      Aperçu de la référence bibliographique
      Chen, J., et al. 2011. Oncogene 30, 4297.
      Li, H., et al. 1999. Phytother. Res. 13, 236.
      Yoon, Y., et al. 1999. Planta Med. 65, 532.
      Hisa, T., et al. 1998. Anticancer Res. 18, 783.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-December-2018 JSW
      SynonymsPyruvate Kinase Inhibitor II
      DescriptionA naphthoquinone found in the Chinese herb Lithospermum erythrorhizon. Possesses significant antibacterial, anti-inflammatory and antitumor activities. Inhibits TNF-α and B-16 melanoma-induced angiogenesis in mice. Blocks the expression of integrin αVβ3 and inhibits endothelial cells proliferation and migration in vitro. Also induces apoptosis in HL60 human promyelocytic leukemia cell line. Selectively blocks PKM2 (IC50 <1 µM) over PKM1 and PKL activities (IC50 in the range of 10-20 µM), and inhibits cancer cell glycolysis.
      FormRed solid
      CAS number517-89-5
      RTECSQL8000200
      Chemical formulaC₁₆H₁₆O₅
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChen, J., et al. 2011. Oncogene 30, 4297.
      Li, H., et al. 1999. Phytother. Res. 13, 236.
      Yoon, Y., et al. 1999. Planta Med. 65, 532.
      Hisa, T., et al. 1998. Anticancer Res. 18, 783.