566324 Sigma-AldrichSIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem
The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: 2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV
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Aperçu
Tableau de caractéristiques principal
| CAS # | Empirical Formula |
|---|---|
| 304896-28-4 | C₂₃H₁₃Cl₂N₃O₂ |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
|---|---|---|---|---|---|---|
| 566324-5MG |
|
Ampoule plast. | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell-permeable quinoline compound that targets the nicotinamide-binding site and acts as a reversible sirtuin 2- (SIRT2) selective inhibitor (IC50 = 3.5 µM) with little activity against SIRT1/3 (IC50 >50 µM). Prevents cellular α-tubulin deacetylation in HeLa cells in a dose-dependent manner and with little cytotoxic effect. Shown to rescue α-Synuclein-mediated toxicity both in primary rat embryo midbrain cultures in vitro and in a Drosophila PD model in vivo. The inactive isomer AGK7 (Cat. No. 566326) can be used as a negative control. |
| Catalogue Number | 566324 |
| Brand Family | Calbiochem® |
| Synonyms | 2-Cyano-3-(5-(2,5-dichlorophenyl)-2-furanyl)-N-5-quinolinyl-2-propenamide, Sirtuin 2 Inhibitor, SIRT2 Inhibitor I, SIRT1 Inhibitor IV |
| References | |
|---|---|
| References | Outerio, T.F., et al. 2007. Science 317, 516. |
| Product Information | |
|---|---|
| CAS number | 304896-28-4 |
| Form | Yellow solid |
| Hill Formula | C₂₃H₁₃Cl₂N₃O₂ |
| Chemical formula | C₂₃H₁₃Cl₂N₃O₂ |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Purity | ≥95% by HPLC |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Référence | GTIN |
| 566324-5MG | 04055977191417 |