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SCC282 SF188 Human Glioblastoma Cell Line

SF188 human glioblastoma cell line is an important cellular model for pediatric human glioblastoma.

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SCC282
≥1X10⁶ cells/vial   
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      Replacement Information
      Description
      Catalogue NumberSCC282
      DescriptionSF188 Human Glioblastoma Cell Line
      Alternate Names
      • SF-188
      • SF 188
      Background InformationGlioblastoma multiforme is the most common and malignant primary brain tumor, with a high recurrence rate and a five-year survival rate of less than 5% (1). Glioblastomas represent approximately 10% of brain tumors in children and pediatric forms often have characteristics distinct from adult forms (2). Glioblastomas are the most aggressive form of cancer, highlighting the importance of relevant human patient-derived cell models for advancing research into characteristics and treatment of this disease.

      SF188 is a patient-derived glioblastoma cell line originating from a right frontal lobe tumor (3). SF188 cells do not express the glial markers GFAP or glutamine synthetase but are positive for laminin and fibronectin expression in early passages, suggestive of proliferative or transformed mesenchymal cells of glioblastoma (3). SF188 cells exhibit hypertriploidy and epithelial morphology in culture and are non-tumorigenic in athymic mice (3). The SF188 cell line possesses genetic amplification of the proliferative factor c-myc (4).

      Source:
      The SF188 glioblastoma cell line was derived from the right frontal lobe tumor of an 8-year-old male patient (3).

      References:
      1. Clin J Oncol Nurs. 2016; 20(5 Suppl): S2-8.
      2. Das KK, Kumar R. Pediatric Glioblastoma. In: De Vleeschouwer S, ed. Glioblastoma. Brisbane (AU): Codon Publications; 2017.
      3. Acta Neuropathol. 1987; 75(1): 92-103.
      4. Proc Natl Acad Sci U.S.A 1986; 83(2): 470-3.
      References
      Product Information
      HS Code3002 90 99
      Applications
      ApplicationSF188 human glioblastoma cell line is an important cellular model for pediatric human glioblastoma.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      SCC282 04061842104086