Millipore Sigma Vibrant Logo

23-030M SCF-Fbw7 Protein Complex, Active, 250 µg

Active complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.

SCF-Fbw7 Protein Complex, Active, 250 µg : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Key Applications: Enzyme Assays
View Products on Sigmaaldrich.com
23-030M
250 µg  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Key ApplicationsSpeciesCascade Component
      Enzyme AssaysHuman E3
      Description
      Catalogue Number23-030M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionSCF-Fbw7 Protein Complex, Active, 250 µg
      OverviewFlocked swab:
      Spray-on Nylon is the secret to flocked swab technology. The short, perpendicular fiber strands produced by the spray on method, creates an absorbent, thin-layer open structure that enhances both sample collection and release through the natural capillary movement of liquid along the fibers. Elution of the liquid and solid specimen sample is rapid and automatic because they are maintained close to the surface of the swab between the nylon strands, spontaneously draining when placed in liquid or onto solid media. Swab shafts are scored at a specific break-point for easy transfer of the tip into transportation media.
      Alternate Names
      • SCFFbxw7
      • SCFhCdc4
      Background InformationThe SCF (Skp1-Cul1-F-box protein) complexes represent the largest family of ubiquitin-protein ligases and mediate the ubiquitination of a broad spectrum of regulatory and signalling proteins in diverse cellular pathways. The SCF consists of three invariant components, Skp1, Cul1, and Rbx1 and an interchangeable subunit, an F-box protein which is responsible for recruiting specific substrates to be ubiquitinated by the SCF. SCFFbw7 mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell division, growth and differentiation, including Cyclin E1, c-Myc, Notch and c-Jun. Mutations have been found in the Fbw7 subunit of SCFFbw7 in various types of human cancers, therefore Fbw7 is considered to be a potent tumour suppressor.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive complex of four (4) full length, recombinant human enzymes: Fbw7, Skp1, Cul1 & Rbx1. For use in Enzyme Assays. Functions as an E3 ligase in ubiquitination assays.
      Key Applications
      • Enzyme Assays
      Biological Information
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Cascade ComponentE3
      Entrez Gene Number
      Purification MethodPurified using glutathione sepharose.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Packaging Information
      Material Size250 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      23-030M 04053252294464

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      23-030 SCF-Fbw7 Protein Complex, Active, 10 µg Prix & Disponibilité

      Familles de produits

      Ubiquitin Proteasome System: Enzymes and Substrates

      Millipore has removed the complexity of Ubiquitination by providing functionally validated enzymes and substrates, making the pathway readily accessible for research and drug discovery.
      En savoir plus >>

      Catégories

      Life Science Research > Drug Discovery and Development > Ubiquitin and Proteasome Screening > Ubiquitin E3 Ligases
      Life Science Research > Proteins and Enzymes > Ubiquitin E3 Ligases