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14-916M PEK, active

PEK, active : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
14-916M
250 µg  Also available in 10μg size as catalog # 14-916 and in 250 μg as catalog # 14-916-K.
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      Aperçu

      Replacement Information
      Description
      Catalogue Number14-916M
      Trade Name
      • Upstate
      DescriptionPEK, active
      OverviewPhosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1)
      References
      Product Information
      PresentationProtein in of 50mM Tris/HCl pH7.5, 300mM NaCl, 0.1mM EGTA, 0.03% Brij-35, 270mM sucrose, 1mM benzamidine, 0.2mM PMSF, 0.1% 2-mercaptoethanol. Frozen solution
      Quality LevelMQ100
      Applications
      Key Applications
      • Kinase Assay
      Biological Information
      SourceN-terminal 6His-tagged, recombinant, human PEK amino acids 536 – end, expressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • PEK
      • PERK
      • EIF2AK3
      Purification MethodPurified using immobilized metal affinity chromatography.
      UniProt Number
      Molecular Weight71 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of the peptide RSRSRSRSRSRSRSR
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10μg size as catalog # 14-916 and in 250 μg as catalog # 14-916-K.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-916M 04053252556319

      Produits & Applications associés

      Alternative Packsize

      Référence Description  
      14-916 PEK Protein, active, 10 µg Prix & Disponibilité

      Familles de produits

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
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      Catégories

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases