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4995 Ouabain, Octahydrate - CAS 11018-89-6 - Calbiochem

Ouabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.

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Synonymes: Strophanthin G

Primary Target: Na+,K+-ATPase
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4995
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Tableau de caractéristiques principal

CAS #Empirical Formula
11018-89-6C₂₉H₄₄O₁₂ · 8H₂O

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      Description
      OverviewInhibits Na+,K+-ATPase. Exhibits cardiotonic properties. Preferentially enhances radiotoxicity in tumor cells and induces apoptosis by prolonging the irradiation-induced G2 delay.
      Catalogue Number4995
      Brand Family Calbiochem®
      SynonymsStrophanthin G
      References
      ReferencesVerheye-Dua, F.A., and Bohm, L. 2000. Strahlenther Onkol. 176, 186.
      Hasenauer, J., et al. 1993. J. Biol. Chem. 268, 3289.
      Rakowski, F.F. 1993. J. Gen. Physiol. 101, 117.
      Mahaney, J.E., and Grisham, C.M. 1992. Biochemistry 31, 2025.
      Xu, Z.J., et al. 1992. J. Physiol. 456, 405.
      Product Information
      CAS number11018-89-6
      ATP CompetitiveN
      FormWhite to off-white solid
      Hill FormulaC₂₉H₄₄O₁₂ · 8H₂O
      Chemical formulaC₂₉H₄₄O₁₂ · 8H₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationOuabain, Octahydrate, CAS 11018-89-6, is an inhibitor of Na+,K+-ATPase. Exhibits cardiotonic properties and enhances radiotoxicity in tumor cells to induce apoptosis.
      Biological Information
      Primary TargetNa+,K+-ATPase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSRN3850000
      Safety Information
      R PhraseR: 26/27/28

      Very toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 2 months at -20°C.
      Global Trade Item Number
      Référence GTIN
      4995-1GM 04055977199253