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494128 Ochratoxin A - CAS 303-47-9 - Calbiochem

Ochratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs).

Ochratoxin A - CAS 303-47-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: OTA, Ochratoxin A, Aspergillus ochraceus

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494128
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Tableau de caractéristiques principal

CAS #Empirical Formula
303-47-9C₂₀H₁₈ClNO₆

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      Description
      OverviewOchratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs). OTA is indicated to play a role in down-regulating the expression of protective enzymes against oxidative stress. It is known to accumulate in several tissues of the body but is primarily localized in the kidney where it impairs proximal tubular functions, and thereby causes nephrotoxicity, glucosuria, enzymuria, and a decrease in the transport of para-aminohippuric acid (PAH). It also acts as an immunosuppressant and as a potent teratogen and carcinogen.
      Catalogue Number494128
      Brand Family Calbiochem®
      SynonymsOTA, Ochratoxin A, Aspergillus ochraceus
      References
      ReferencesAnzai, N., et al. 2010. Toxins 2, 1381.
      Chopra, M., et al. 2010. Cell Biol. Toxicol. 26, 239.
      Luhe, A., et al. 2002. Tox. Sci. 73, 315.
      Dirheimer, G., et al. 1991. IARC Swci Publ. 115, 171.
      Product Information
      CAS number303-47-9
      FormOff-white powder
      Hill FormulaC₂₀H₁₈ClNO₆
      Chemical formulaC₂₀H₁₈ClNO₆
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 28-38-60-61

      Very toxic if swallowed.
      Irritating to skin.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 24/25-36/37/39-45

      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      494128-1MG 04055977272864

      Documentation

      Ochratoxin A - CAS 303-47-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Ochratoxin A - CAS 303-47-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      494128

      Références bibliographiques

      Aperçu de la référence bibliographique
      Anzai, N., et al. 2010. Toxins 2, 1381.
      Chopra, M., et al. 2010. Cell Biol. Toxicol. 26, 239.
      Luhe, A., et al. 2002. Tox. Sci. 73, 315.
      Dirheimer, G., et al. 1991. IARC Swci Publ. 115, 171.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-October-2016 JSW
      SynonymsOTA, Ochratoxin A, Aspergillus ochraceus
      DescriptionOchratoxin A (OTA) is a mycotoxin that acts through mechanisms such as the inhibition of protein synthesis, and may also be mediated by organic anion transporters (OATs). OTA is indicated to play a role in down-regulating the expression of protective enzymes against oxidative stress. It is known to accumulate in several tissues of the body but is primarily localized in the kidney where it impairs proximal tubular functions, and thereby causes nephrotoxicity, glucosuria, enzymuria, and a decrease in the transport of para-aminohippuric acid (PAH). It also acts as an immunosuppressant and as a potent teratogen and carcinogen.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number303-47-9
      Chemical formulaC₂₀H₁₈ClNO₆
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (50 mg/ml; nearly colorless solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Highly Toxic & Carcinogenic / Teratogenic
      ReferencesAnzai, N., et al. 2010. Toxins 2, 1381.
      Chopra, M., et al. 2010. Cell Biol. Toxicol. 26, 239.
      Luhe, A., et al. 2002. Tox. Sci. 73, 315.
      Dirheimer, G., et al. 1991. IARC Swci Publ. 115, 171.