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487928 Nocodazole - CAS 31430-18-9 - Calbiochem

Nocodazole, CAS 31430-18-9, is a highly specific anti-microtubular agent that promotes tubulin depolymerization and inhibits mitosis.

Nocodazole - CAS 31430-18-9 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: R17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate

Primary Target: Promotes tubulin depolymerization
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487928
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
31430-18-9C₁₄H₁₁N₃O₃S

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487928-10MG
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      		 Ampoule plast. 10 mg
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      Description
      OverviewInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also available as a 50 mM solution in DMSO (Cat. No. 487929).
      Catalogue Number487928
      Brand Family Calbiochem®
      SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
      References
      ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
      Bunz, F., et al. 1998. Science 282, 1497.
      Fleischman, L.F., et al. 1993. Oncogene 8, 771.
      Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
      Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
      Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
      Product Information
      CAS number31430-18-9
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₁₄H₁₁N₃O₃S
      Chemical formulaC₁₄H₁₁N₃O₃S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationNocodazole, CAS 31430-18-9, is a highly specific anti-microtubular agent that promotes tubulin depolymerization and inhibits mitosis.
      Biological Information
      Primary TargetPromotes tubulin depolymerization
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDD6521000
      Safety Information
      R PhraseR: 40-63

      Limited evidence of a carcinogenic effect.
      Possible risk of harm to the unborn child.
      S PhraseS: 36

      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      487928-10MG 04055977200386

      Documentation

      Nocodazole - CAS 31430-18-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Nocodazole - CAS 31430-18-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      487928

      Références bibliographiques

      Aperçu de la référence bibliographique
      Park, H., et al. 2011. Chem. Med. Chem. in press.
      Bunz, F., et al. 1998. Science 282, 1497.
      Fleischman, L.F., et al. 1993. Oncogene 8, 771.
      Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
      Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
      Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.

      Citations

      Titre
    • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2012 JSW
      SynonymsR17934, Methyl-[5-(2-thienylcarbonyl)-1H-benzimidazol-2-yl]-carbamate
      DescriptionInhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture. Promotes tubulin depolymerization. Also acts as a high-affinity ligand for the cancer-related kinases ABL, c-KIT, BRAF, and MEK (Kd < 2 µM).
      FormPale yellow solid
      CAS number31430-18-9
      RTECSDD6521000
      Chemical formulaC₁₄H₁₁N₃O₃S
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long-term storage or refrigerate (4°C) for short-term storage. Stock solutions are stable for up to 1 week at 4°C or for up to 1 year at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesPark, H., et al. 2011. Chem. Med. Chem. in press.
      Bunz, F., et al. 1998. Science 282, 1497.
      Fleischman, L.F., et al. 1993. Oncogene 8, 771.
      Pomies, P., and Block, M.R. 1992. Biochem. Biophys. Res. Commun. 189, 1429.
      Rennison, M.E., et al. 1992. J. Cell Sci. 102, 239.
      Thyberg, J., and Moskalewski, S. 1992. J. Cell Sci. 103, 1167.
      Citation
    • Meng Qiao, et al. (2006) Cell cycle-dependent phosphorylation of the RUNX2 transcription factor by cdc2 regulates endothelial cell proliferation. Journal of Biological Chemistry 281, 7118-7128.
      		•