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490070 Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem

The Nitric Oxide Synthase, Neuronal Inhibitor I, also referenced under CAS 357965-99-2, controls the biological activity of neuronal Nitric Oxide Synthase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA

Primary Target: nNOS
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490070
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Tableau de caractéristiques principal

CAS #Empirical Formula
357965-99-2C₈H₂₁N₇O₂ · 3TFA · 2H₂O

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      Description
      OverviewA cell-permeable, potent and highly selective inhibitor of neuronal nitric oxide synthase (nNOS); (Ki = 120 nM). Displays >2500-fold and 320-fold selectivity over eNOS and iNOS, respectively.
      Catalogue Number490070
      Brand Family Calbiochem®
      Synonyms(4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA
      References
      ReferencesHah, J.M., et al. 2001. J. Med. Chem. 44, 2667.
      Product Information
      CAS number357965-99-2
      ATP CompetitiveN
      FormWhite to off-white solid
      FormulationSupplied as a dihydrate.
      Hill FormulaC₈H₂₁N₇O₂ · 3TFA · 2H₂O
      Chemical formulaC₈H₂₁N₇O₂ · 3TFA · 2H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetnNOS
      Primary Target K<sub>i</sub>120 nM against nNOS
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      490070-5MG 04055977273410

      Documentation

      Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Nitric Oxide Synthase, Neuronal Inhibitor I - CAS 357965-99-2 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      490070

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hah, J.M., et al. 2001. J. Med. Chem. 44, 2667.

      Brochure

      Titre
      Pathways and Biomarkers of Oxidative Stress
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-July-2010 JSW
      Synonyms(4S)-N-(4-Amino-5[aminoethyl]aminopentyl)-Nʹ-nitroguanidine, TFA
      DescriptionA cell-permeable, potent, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS) (Ki = 120 nM). Displays >2,500-fold and 192-fold selectivity over eNOS and iNOS, respectively.
      FormWhite to off-white solid
      FormulationSupplied as a dihydrate.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number357965-99-2
      Chemical formulaC₈H₂₁N₇O₂ · 3TFA · 2H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesHah, J.M., et al. 2001. J. Med. Chem. 44, 2667.