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20-221 NAD Cofactor

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20-221
10 mg  
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Key Applications
      HDAC
      Description
      Catalogue Number20-221
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionNAD Cofactor
      OverviewDescription: β-nicotinamide adenine dinucleotide hydrate

      FW: 663.4

      Use: Can be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.
      References
      Product Information
      Presentationlyophilized powder
      Quality LevelMQ100
      Applications
      ApplicationCan be used as a cofactor in reactions with NAD-dependent histone deacetylase enzymes.
      Key Applications
      • Histone Deacetylase Assay (HDAC)
      Biological Information
      Entrez Gene Number
      Entrez Gene SummaryIsocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase.
      Gene Symbol
      • IDH3A
      • NAD
      UniProt Number
      UniProt SummaryCOFACTOR: Binds 1 magnesium or manganese ion per subunit (By similarity).
      SIZE: 366 amino acids; 39592 Da
      SUBUNIT: Heterooligomer of subunits alpha, beta, and gamma in the apparent ratio of 2:1:1 (By similarity).
      SUBCELLULAR LOCATION: Mitochondrion.
      SIMILARITY: SwissProt: P50213 ## Belongs to the isocitrate and isopropylmalate dehydrogenases family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions1 year at room temperature
      Packaging Information
      Material Size10 mg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      20-221 04053252322129

      Documentation

      NAD Cofactor FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      NAD Cofactor Certificats d'analyse

      TitreNuméro de lot
      NAD Cofactor 2866689
      NAD Cofactor 2483903
      NAD Cofactor - 26316 26316
      NAD Cofactor - 31633 31633
      NAD Cofactor - 3322746 3322746
      NAD Cofactor - 33518 33518
      NAD Cofactor - 3718581 3718581
      NAD Cofactor - 3862030 3862030
      NAD Cofactor - 3884318 3884318
      NAD Cofactor - 4003035 4003035

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Nanostructured lipid carriers (NLC) on the basis of Siberian pine (Pinus sibirica) seed oil.
      E S Averina,G Seewald,R H Müller,L D Radnaeva,D V Popov
      Die Pharmazie  65  2009

      Afficher le résumé
      20187575 20187575
      Effects of perfluorocarbon emulsions on cultured human endothelial cells.
      M Mathy-Hartert,M P Krafft,C Deby,G Deby-Dupont,M Meurisse,M Lamy,J G Riess
      Artificial cells, blood substitutes, and immobilization biotechnology  25  1997

      Afficher le résumé
      9352061 9352061
      The correlation of plasma and urine endothelin-1 with the severity of nephropathy in Chinese patients with type 2 diabetes.
      S J Shin,Y J Lee,J H Tsai
      Scandinavian journal of clinical and laboratory investigation  56  1996

      Afficher le résumé
      8903119 8903119
      Matrix-assisted laser-desorption/ionization mass spectrometric approaches for the identification of gel-separated proteins in the 5-50 pmol range.
      S D Patterson
      Electrophoresis  16  1994

      Afficher le résumé
      7498154 7498154
      Biological activity of prostate-specific antigen isolated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and electroelution.
      U Tessmer,T Quack,F Donn,A Leuner,R Dernick
      Electrophoresis  16  1994

      Afficher le résumé
      7588564 7588564
      Monoclonal antibodies to murine CD40 define two distinct functional epitopes.
      A W Heath,W W Wu,M C Howard
      European journal of immunology  24  1993

      Afficher le résumé
      7519997 7519997
      Interleukins (IL)-1 and IL-2 control IL-2 receptor alpha and beta expression in immature thymocytes.
      A Wilson,P Corthésy,P Reichenbach,H R MacDonald,M Nabholz
      European journal of immunology  24  1993

      Afficher le résumé
      8056031 8056031
      Two different genes from Schwanniomyces occidentalis determine ribosomal resistance to cycloheximide.
      L Del Pozo,D Abarca,J Hoenicka,A Lmenez
      European journal of biochemistry / FEBS  213  1992

      Afficher le résumé
      8477754 8477754
      Activation of the CD3/T cell receptor (TcR) complex or of protein kinase C potentiate adenylyl cyclase stimulation in a tumoral T cell line: involvement of two distinct intracellular pathways.
      C Bihoreau,A Heurtier,A Enjalbert,N Corvaïa,A Bensussan,L Degos,C Kordon
      European journal of immunology  21  1991

      Afficher le résumé
      1657616 1657616
      Inhibition by aminoacyl-chloromethane protease inhibitors of superoxide anion production by phorbol-ester-stimulated human neutrophils. The labeled target is a membrane protein.
      E C Conseiller,D Schott,F Lederer
      European journal of biochemistry / FEBS  193  1990

      Afficher le résumé
      2171934 2171934