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444293 MMP-9 Inhibitor II - CAS 502887-71-0 - Calbiochem

The MMP-9 Inhibitor II controls the biological activity of MMP-9. This small molecule/inhibitor is primarily used for Biochemicals applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: MMP-9 PEX Inhibitor

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444293
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Aperçu

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Tableau de caractéristiques principal

CAS #Empirical Formula
502887-71-0C₁₆H₁₇F₂N₃O₃S

Prix & Disponibilité

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444293-10MG
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      Description
      OverviewThis compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a Kd = 2.1 µM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100 µM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100 µM, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20 mg/kg, 6 days/week, i.v. and i.t.).
      Catalogue Number444293
      Brand Family Calbiochem®
      SynonymsMMP-9 PEX Inhibitor
      References
      ReferencesDufour, A., et al. 2011. Cancer Res. 71, 4977.
      Product Information
      CAS number502887-71-0
      FormYellow-white solid
      Hill FormulaC₁₆H₁₇F₂N₃O₃S
      Chemical formulaC₁₆H₁₇F₂N₃O₃S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      444293-10MG 04055977186093

      Documentation

      MMP-9 Inhibitor II - CAS 502887-71-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      MMP-9 Inhibitor II - CAS 502887-71-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      444293

      Références bibliographiques

      Aperçu de la référence bibliographique
      Dufour, A., et al. 2011. Cancer Res. 71, 4977.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-April-2012 JSW
      SynonymsMMP-9 PEX Inhibitor
      DescriptionThis compound is a cell-permeable, selective, and reversible thiopyrimidone MMP-9 allosteric inhibitor that binds specifically to the non-catalytic site of MMP-9 at the PEX domain with a Kd = 2.1 µM and thereby disrupts MMP-9 homodimerization and its cross-talk with CD44 and the EGFR-MAPK signaling pathway. It does not bind to the PEX domain of MMP-2 or MT1-MMP and it is shown to decrease MMP-9 mediated cell migration in COS-1 cells at 100 µM. Also, it inhibits cell migration and invasion of HT-1080 and MDA-MB-435 human cancer cells in a dose-dependent manner from 0.1 to 100 µM, without altering MMP-9 expression or proteolytic activity in HT-1080 cells. In addition, it attenuates both primary tumor growth and metastasis in vivo in a mouse model without obvious toxicity (20 mg/kg, 6 days/week, i.v. and i.t.).
      FormYellow-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number502887-71-0
      Chemical formulaC₁₆H₁₇F₂N₃O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml; light yellow solution)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDufour, A., et al. 2011. Cancer Res. 71, 4977.