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475882 ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem

A cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 µM), protein kinase A (Ki = 32 µM), and protein kinase C (Ki = 54 µM).

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl

Primary Target: Mlck
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475882
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Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
105637-50-1C₁₅H₁₇ClN₂O₂S · HCl

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      Description
      OverviewA cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 µM), protein kinase A (Ki = 32 µM), and protein kinase C (Ki = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.
      Catalogue Number475882
      Brand Family Calbiochem®
      Synonyms1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
      References
      ReferencesReig, J.A., et al. 1993. Neurochem. Res. 18, 317.
      Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1045.
      Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
      Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun. 140, 280.
      Product Information
      CAS number105637-50-1
      ATP CompetitiveY
      FormWhite solid
      Hill FormulaC₁₅H₁₇ClN₂O₂S · HCl
      Chemical formulaC₁₅H₁₇ClN₂O₂S · HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMlck
      Primary Target K<sub>i</sub>3.8 µM, 32 µM, 54 µM against myosin light chain kinase, protein kinase A, and protein kinase C, respectively
      Purity≥98% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      475882-1MG 04055977203509

      Documentation

      ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      ML-9, Hydrochloride - CAS 105637-50-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      475882

      Références bibliographiques

      Aperçu de la référence bibliographique
      Reig, J.A., et al. 1993. Neurochem. Res. 18, 317.
      Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1045.
      Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
      Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun. 140, 280.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-September-2018 JSW
      Synonyms1-(5-Chloronaphthalene-1-sulfonyl)homopiperazine, HCl
      DescriptionA cell-permeable, reverisible and ATP-competitive inhibitor of myosin light chain kinase (Ki = 3.8 µM), protein kinase A (Ki = 32 µM), and protein kinase C (Ki = 54 µM). Also inhibits catecholamine secretion in intact and permeabilized chromaffin cells.
      FormWhite solid
      CAS number105637-50-1
      Chemical formulaC₁₅H₁₇ClN₂O₂S · HCl
      Structure formulaStructure formula
      Purity≥98% by TLC
      Solubility50% Ethanol (10 mg/ml). Further dilute with aqueous buffer just prior to use.
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesReig, J.A., et al. 1993. Neurochem. Res. 18, 317.
      Nagatsu, T., et al. 1987. Biochem. Biophys. Res. Commun. 143, 1045.
      Saitoh, M., et al. 1987. J. Biol. Chem. 262, 7796.
      Saitoh, M., et al. 1986. Biochem. Biophys. Res. Commun. 140, 280.