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14-303M MKK6/SKK3 Protein, active, 250 µg

Active, N-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end. For use in Kinase Assays.

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14-303M
250 µg  Also available in 10 μg size (cat#14-303) and in bulk (cat# 14-303-K).
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      Replacement Information
      Description
      Catalogue Number14-303M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMKK6/SKK3 Protein, active, 250 µg
      OverviewN-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end.
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal, maltose binding protein tagged, human MKK6/SKK3 fusion protein, amino acids 4-end. For use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      SourceExpressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the dual specificity protein kinase family, which functions as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein phosphorylates and activates p38 MAP kinase in response to inflammatory cytokines or environmental stress. As an essential component of p38 MAP kinase mediated signal transduction pathway, this gene is involved in many cellular processes such as stress induced cell cycle arrest, transcription activation and apoptosis.
      Gene Symbol
      • MAP2K6
      • PRKMK6
      • MEK6
      • SAPKK3
      • MAPKK6
      • MKK6
      Protein TargetMKK6
      Purification MethodAmylose Resin Beads
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P52564 # Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in MAP kinase p38 exclusively.
      SIZE: 334 amino acids; 37492 Da
      SUBUNIT: Interacts with Yersinia yopJ.
      TISSUE SPECIFICITY: Isoform 2 is only expressed in skeletal muscle. Isoform 1, on the other hand, is found in skeletal muscle, heart, and in lesser extent in liver or pancreas.
      PTM: Weakly autophosphorylated. & Acetylation of Ser-207 and Thr-211 by Yersinia yopJ prevents phosphorylation and activation, thus blocking the MAPK signaling pathway.
      SIMILARITY: SwissProt: P52564 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight82kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of unactive p38α/SAPK2a.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -70°C
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-303) and in bulk (cat# 14-303-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-303M 04053252731310

      Documentation