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14-378 MKK4/SKK1 Protein, inactive, 50 µg

Inactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.

MKK4/SKK1 Protein, inactive, 50 µg : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
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14-378
50 µg  
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      Aperçu

      Replacement Information
      Description
      Catalogue Number14-378
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMKK4/SKK1 Protein, inactive, 50 µg
      OverviewRecombinant mouse MKK4, corresponding to amino acids 35-397, fused to an Nterminal GST-tag
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationInactive, recombinant mouse MKK4, corresponding to amino acids 35-397, fused to an N-terminal GST-tag, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a dual specificity protein kinase that belongs to the Ser/Thr protein kinase family. This kinase is a direct activator of MAP kinases in response to various environmental stresses or mitogenic stimuli. It has been shown to activate MAPK8/JNK1, MAPK9/JNK2, and MAPK14/p38, but not MAPK1/ERK2 or MAPK3/ERK3. This kinase is phosphorylated, and thus activated by MAP3K1/MEKK. The knockout studies in mice suggested the roles of this kinase in mediating survival signal in T cell development, as well as in the organogenesis of liver.
      Gene Symbol
      • MAP2K4
      • MKK4
      • JNKK
      • MEK4
      • MAPKK4
      • JNKK1
      • SEK1
      • SERK1
      • PRKMK4
      Protein TargetMKK4
      Purification MethodGSH-agarose chromatography
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P45985 # Dual specificity kinase that activates the JUN kinases MAPK8 (JNK1) and MAPK9 (JNK2) as well as MAPK14 (p38) but not MAPK1 (ERK2) or MAPK3 (ERK1).
      SIZE: 399 amino acids; 44288 Da
      SUBUNIT: Interacts with SPAG9 (By similarity).
      TISSUE SPECIFICITY: Abundant expression is seen in the skeletal muscle. It is also widely expressed in other tissues.
      PTM: Activated by phosphorylation on Ser/Thr by MAP kinase kinase kinases (By similarity).
      SIMILARITY: SwissProt: P45985 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. & Contains 1 protein kinase domain.
      Molecular Weight65kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of ATF2 substrate
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20C
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      14-378 04053252738623

      Documentation

      MKK4/SKK1 Protein, inactive, 50 µg FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      MKK4/SKK1 Protein, inactive, 50 µg Certificats d'analyse

      TitreNuméro de lot
      MKK4/SKK1, unactive - 30901U-B 30901U-B
      MKK4/SKK1, unactive - 30901U-C 30901U-C

      Références bibliographiques

      Aperçu de la référence bibliographiqueApplicationNº PubMed
      MRK, a mixed lineage kinase-related molecule that plays a role in gamma-radiation-induced cell cycle arrest
      Gross, E. A., et al
      J Biol Chem, 277:13873-82 (2002)  2002

      		Kinase Assay11836244 11836244