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475863 MK2a Inhibitor - CAS 41179-33-3 - Calbiochem

The MK2a Inhibitor, also referenced under CAS 41179-33-3, controls the biological activity of MK2a. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MK2a Inhibitor - CAS 41179-33-3 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: MAPKAPK2a Inhibitor, Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1

Primary Target: Mk2α
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475863
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Tableau de caractéristiques principal

CAS #Empirical Formula
41179-33-3C₂₂H₂₀FNO₂

Prix & Disponibilité

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475863-5MG
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      Description
      OverviewA reversible p-amidophenolic compound that selectively inhibits the phosphorylation of MK2a (mitogen-activated protein kinase-activated protein kinase 2a; Kiapp = 330 nM) by p38α in a non-ATP-competitive manner. Does not block the kinase activity of p38α towards the other two known p38 substrates, MBP and ATF-2.
      Catalogue Number475863
      Brand Family Calbiochem®
      SynonymsMAPKAPK2a Inhibitor, Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1
      References
      ReferencesDavidson, W., et al. 2004. Biochemistry 43, 11658.
      Lukas, S.M., et al. 2004. Biochemistry 43, 9950.
      Product Information
      CAS number41179-33-3
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₂₂H₂₀FNO₂
      Chemical formulaC₂₂H₂₀FNO₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMk2α
      Primary Target K<sub>i</sub>Kiapp = 330 nM against mitogen-activated protein kinase-activated protein kinase 2a (MK2a)
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      475863-5MG 04055977203394

      Documentation

      MK2a Inhibitor - CAS 41179-33-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      MK2a Inhibitor - CAS 41179-33-3 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      475863

      Références bibliographiques

      Aperçu de la référence bibliographique
      Davidson, W., et al. 2004. Biochemistry 43, 11658.
      Lukas, S.M., et al. 2004. Biochemistry 43, 9950.

      Posters

      Titre
      Human Kinome & InhibitorSelect™ Libraries
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      SynonymsMAPKAPK2a Inhibitor, Mitogen-activated protein kinase-activated protein kinase 2a Inhibitor, 4-(2ʹ-Fluorobiphenyl-4-yl)-N-(4-hydroxyphenyl)-butyramide, CMPD1
      DescriptionA non-ATP-competitive, reversible, selective inhibitor of p38α-mediated MK2a (mitogen-activated protein kinase-activated protein kinase 2a) phosphorylation (Kiapp = 330 nM). Does not inhibit p38α-mediated phosphorylation of the the other two known p38 substrates, MBP and ATF-2.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number41179-33-3
      Chemical formulaC₂₂H₂₀FNO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesDavidson, W., et al. 2004. Biochemistry 43, 11658.
      Lukas, S.M., et al. 2004. Biochemistry 43, 9950.