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119113 Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem

The Luciferase Inhibitor I, also referenced under CAS 352341-26-5, controls the biological activity of Luciferase.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine

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119113
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Tableau de caractéristiques principal

CAS #Empirical Formula
352341-26-5C₁₄H₁₁N₃O₂

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119113-5MG
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      Description
      OverviewA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
      Catalogue Number119113
      Brand Family Calbiochem®
      Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
      References
      ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
      Product Information
      CAS number352341-26-5
      DeclarationMarketed by Promega Corp. under the registered trademarks.
      FormOff-white solid
      Hill FormulaC₁₄H₁₁N₃O₂
      Chemical formulaC₁₄H₁₁N₃O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      119113-5MG 04055977223231

      Documentation

      Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Luciferase Inhibitor I - CAS 352341-26-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      119113

      Références bibliographiques

      Aperçu de la référence bibliographique
      Auld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-April-2011 RFH
      Synonyms2-(5-(2-Methoxyphenyl)-1,2,4-oxadiazol-3-yl)pyridine
      DescriptionA 3,5-diaryl-oxadiazole compound that acts as an inhibitor against the ATP-dependent Photuris pennsylvanica (lucPpe) and Photinus pyralis (lucPpy) luciferase activity (IC50 = 0.08 and 2.8 µM, respectively, with 10 µM ATP, 10 µM luciferin, and 10 nM respective enzyme) and effectively inhibits lucPpe-based commercial luciferase-luciferin formulations (IC50 = 5, 13.5, and 12.7 µM against Promega's Kinase-Glo®, Kinase-Glo® Plus, and Kinase-Glo® Max, respectively, at a 3-fold formulation dilution and 6.77 µM ATP). Unlike Luciferase Inhibitor II (Cat. No. 119114), Luciferase Inhibitor I is noncompetitive with respect to either luciferin or ATP.
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number352341-26-5
      Chemical formulaC₁₄H₁₁N₃O₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (50 mg/ml) or Ethanol (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesAuld, D.S., et al. 2009. J. Med. Chem. 52, 1450.
      Auld, D.S., et al. 2008. J. Med. Chem. 51, 2372.