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506291 Lactimidomycin - CAS 134869-15-1 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 506291) on sigmaaldrich.com.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: LTM

Primary Target: Ribosome
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506291
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Tableau de caractéristiques principal

CAS #Empirical Formula
134869-15-1C₂₆H₃₅NO₆

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      Description
      OverviewA glutarimide based 12-membered macrolide antibiotic with antifungal properties. Acts as a potent inhibitor of cell migration, cell proliferation, and protein synthesis (IC50 = 37.82 nM), but does not affect RNA synthesis even at high concentrations (IC50 > 10 µM). Acts as a potent inhibitor of translation and appears to block the first translocation step without affecting tRNA binding or peptide bond formation. It exhibits about 10-fold greater potency than cycloheximide (Cat. No. 239763 and 239764). Binds to the same site on the 60S ribosomal subunit with high affinity (Kd = 500 nM vs 15 µM for cycloheximide). Shown to extend the survival of mice bearing P388 lymphoma by blocking cell growth, however, it does not significantly affect non-tumorigenic MCF10A breast cell lines. Also shown to retard the growth of MDA MB231 cells in nude mice (~0.6 /mg/kg).
      Catalogue Number506291
      Brand Family Calbiochem®
      SynonymsLTM
      References
      ReferencesSchneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
      Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
      Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
      Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.
      Product Information
      CAS number134869-15-1
      FormWhite powder
      Hill FormulaC₂₆H₃₅NO₆
      Chemical formulaC₂₆H₃₅NO₆
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetRibosome
      Primary Target IC<sub>50</sub>37.8 nM, Kd
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5062910001 04055977243215

      Documentation

      Lactimidomycin - CAS 134869-15-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Schneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
      Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
      Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
      Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.

      Brochure

      Titre
      New Products Flyer- Feb 2014 - Vol 1
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-September-2013 JSW
      SynonymsLTM
      DescriptionA glutarimide based 12-membered macrolide antibiotic with antifungal properties. Acts as a potent inhibitor of cell migration, cell proliferation, and protein synthesis (IC50 = 37.82 nM), but does not affect RNA synthesis even at high concentrations (IC50 > 10 µM). Acts as a potent inhibitor of translation and appears to block the first translocation step without affecting tRNA binding or peptide bond formation. It exhibits about 10-fold greater potency than cycloheximide (Cat. No. 239763 and 239764). Binds to the same site on the 60S ribosomal subunit with high affinity (Kd = 500 nM vs 15 µM for cycloheximide). Shown to extend the survival of mice bearing P388 lymphoma by blocking cell growth, however, it does not significantly affect non-tumorigenic MCF10A breast cell lines. Also shown to retard the growth of MDA MB231 cells in nude mice (~0.6 /mg/kg).
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number134869-15-1
      Chemical formulaC₂₆H₃₅NO₆
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSchneider-Poetsch, T., et al. 2010. Nat. Chem. Biol. 6, 209.
      Micoine, K., et al. 2010. J. Am. Chem. Soc. 132, 14064.
      Ju, J., et al. 2009. J. Am. Chem. Soc. 131, 1370.
      Sugawara, K., et al. 1992. J. Antibiot. 45, 1433.