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420129 JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

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Tableau de caractéristiques principal

CAS #Empirical Formula
345987-15-7C₂₀H₁₆N₆S

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420129-5MG
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      Description
      OverviewA cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
      Catalogue Number420129
      Brand Family Calbiochem®
      SynonymsSAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
      References
      ReferencesGaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
      Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
      Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
      Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.
      Product Information
      CAS number345987-15-7
      ATP CompetitiveY
      FormYellow solid
      Hill FormulaC₂₀H₁₆N₆S
      Chemical formulaC₂₀H₁₆N₆S
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Application CommentsSoluble in DMSO, aliquot & store at -20*C; stable for 3 months
      Biological Information
      Primary TargethJNK 1, hJNK 2, hJNK 3
      Primary Target IC<sub>50</sub>150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively
      Purity≥95% by HPLC (sum of two isomers)
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      420129-5MG 04055977188073