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420139 JAK2 Inhibitor IV - CAS 1110502-30-1 - Calbiochem

The JAK2 Inhibitor IV, also referenced under CAS 1110502-30-1, controls the biological activity of JAK2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole

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420139
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Tableau de caractéristiques principal

CAS #Empirical Formula
1110502-30-1C₁₇H₂₀N₄O₂S

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420139-5MG
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      		 Ampoule plast. 5 mg
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      Description
      OverviewAn aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
      Catalogue Number420139
      Brand Family Calbiochem®
      Synonyms3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole
      References
      ReferencesAntonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.
      Product Information
      CAS number1110502-30-1
      FormPale yellow solid
      Hill FormulaC₁₇H₂₀N₄O₂S
      Chemical formulaC₁₇H₂₀N₄O₂S
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      420139-5MG 04055977187687

      Documentation

      JAK2 Inhibitor IV - CAS 1110502-30-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      JAK2 Inhibitor IV - CAS 1110502-30-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      420139

      Références bibliographiques

      Aperçu de la référence bibliographique
      Antonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.

      Brochure

      Titre
      Pathways and Biomarkers of JAK/STAT Signaling

      Informations techniques

      Titre
      JAK/STAT Signaling Research Focus
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-April-2011 RFH
      Synonyms3-Amino-5-(N-tert-butylsulfonamido-4-phenyl)-indazole
      DescriptionAn aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the constitutively active V617F mutant (IC50 = 78 and 206 nM, respectively) frequently found in patients with clonal polycythemia vera, essential thrombocytosis, and chronic idiopathic myelofibrosis, while exhibiting much reduced activity against JAK3 (IC50 = 2.93 µM).
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1110502-30-1
      Chemical formulaC₁₇H₂₀N₄O₂S
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml) or Ethanol (3 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesAntonysamy, S., et al. 2008. Bioorg. Med. Chem. Lett. 19, 279.