420099 Sigma-AldrichJAK Inhibitor I - CAS 457081-03-7 - Calbiochem
JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC₅₀ = 1 nM).
More>> JAK Inhibitor I, CAS 457081-03-7, is a potent, reversible, cell-permeable, and ATP-competitive inhibitor of JAK 1 (IC₅₀ = 15 nM), JAK2 (IC₅₀ = 1 nM), JAK3 (Ki = 5 nM) and Tyk2 (IC₅₀ = 1 nM). Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 457081-03-7 | C₁₈H₁₆FN₃O |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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| 420099-1MG |
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Ampoule plast. | 1 mg |
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| 420099-500UG |
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Ampoule plast. | 500 μg |
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| Description | |
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| Overview | A potent, reversible, cell-permeable, and ATP-competitive inhibitor of Janus protein tyrosine kinases (JAKs). Displays potent inhibitory activity against JAK1 (IC50 = 15 nM for murine JAK1), JAK2 (IC50 = 1 nM), JAK3 (Ki = 5 nM), and Tyk2 (IC50 = 1 nM). Inhibits other kinases at much higher concentrations. Shown to inhibit IL2- and IL4-dependent proliferation of CTLL cells and block the phosphorylation of STAT5; and further induce growth inhibition of multiple myeloma cells expressing activated JAKs and STAT3, unlike AG 490 (Cat. No. 658401). A 10 mM (500 µg/162 µl) solution of JAK Inhibitor I (Cat. No. 420097) in DMSO is also available. |
| Catalogue Number | 420099 |
| Brand Family | Calbiochem® |
| Synonyms | 2-(1,1-Dimethylethyl)-9-fluoro-3,6-dihydro-7H-benz[h]-imidaz[4,5-f]isoquinolin-7-one, Pyridone 6, P6, DBI, JAK1 Inhibitor I, JAK2 Inhibitor I, JAK3 Inhibitor X |
| References | |
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| References | Pedranzini, L., et al. 2006. Cancer Res. 66, 9714. Lucet, I.S., et al. 2005. Blood 107, 176. Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219. |
| Product Information | |
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| CAS number | 457081-03-7 |
| ATP Competitive | Y |
| Form | Off-white solid |
| Hill Formula | C₁₈H₁₆FN₃O |
| Chemical formula | C₁₈H₁₆FN₃O |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 420099-1MG | 04055977187878 |
| 420099-500UG | 04055977187885 |
Documentation
JAK Inhibitor I - CAS 457081-03-7 - Calbiochem FDS
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JAK Inhibitor I - CAS 457081-03-7 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 420099 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Pedranzini, L., et al. 2006. Cancer Res. 66, 9714. Lucet, I.S., et al. 2005. Blood 107, 176. Thompson, J.E., et al. 2002. Bioorg. Med. Chem. Lett. 12, 1219. |
Brochure
| Titre |
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| An Introduction to Inhibitors and Their Biological Applications - 1st Edition |
| Pathways and Biomarkers of JAK/STAT Signaling |
Informations techniques
| Titre |
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| JAK/STAT Signaling Research Focus |
Fiche technique
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| Reprogramming Cell Fate and Function Novel Strategies for iPSC Generation, Characterization, and Differentiation |
Citations
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