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553590 InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem

A cell-permeable polyketide that displays potent antitumor properties in eukaryotes.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Ratjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II

Primary Target: nuclear export of LR-NES
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553590
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Tableau de caractéristiques principal

CAS #Empirical Formula
163564-92-9C₂₈H₄₀O₅

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      Description
      OverviewA cell-permeable polyketide that displays potent antitumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeasts and filamentous fungi, ratjadones inhibit nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤ 1 ng/ml) and induces cell cycle arrest at G1 phase.
      Catalogue Number553590
      Brand Family Calbiochem®
      SynonymsRatjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
      References
      ReferencesKöster, M., et al. 2003. Exp. Cell Res. 286, 321.
      Kalesse, M., et al. 2001. Chem biochem 2, 709.
      Gerth, K., et al. 1995. J. Antibiot. 48, 973.
      Product Information
      CAS number163564-92-9
      ATP CompetitiveN
      FormLiquid
      FormulationA 5 µg/ml solution (2 µg in 400 µl) in methanol.
      Hill FormulaC₂₈H₄₀O₅
      Chemical formulaC₂₈H₄₀O₅
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetnuclear export of LR-NES
      Primary Target IC<sub>50</sub>≤ 1 ng/ml for inhibiting proliferation and inducing cell cycle arrest at G1 phase
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      553590-2UG 04055977193763

      Documentation

      InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ Ratjadone A, Synthetic - CAS 163564-92-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      553590

      Références bibliographiques

      Aperçu de la référence bibliographique
      Köster, M., et al. 2003. Exp. Cell Res. 286, 321.
      Kalesse, M., et al. 2001. Chem biochem 2, 709.
      Gerth, K., et al. 1995. J. Antibiot. 48, 973.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision09-September-2008 RFH
      SynonymsRatjadon, Chromosome Region Maintenance 1 Protein Inhibitor II, CRM1 Inhibitor II, Exportin 1 Inhibitor II, XPO1 Inhibitor II
      DescriptionA cell-permeable polyketide that displays potent anti-tumor properties in eukaryotes. Originally identified as a metabolite from the myxobacterium Sorangium cellulosum for its antibiotic activities against yeast and filamentous fungi. Ratjadones act by inhibiting nuclear export of LR-NES (leucine rich-nuclear export signal)-containing proteins by covalently binding to CRM1. Inhibits proliferation (IC50 ≤1 ng/ml) and induces cell cycle arrest at the G1 phase.
      FormLiquid
      FormulationA 5 µg/ml solution (2 µg in 400 µl) in methanol.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number163564-92-9
      Chemical formulaC₂₈H₄₀O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityMethanol (20 mg/ml) or aqueous buffers (≤100 µM)
      Storage Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Flammable
      ReferencesKöster, M., et al. 2003. Exp. Cell Res. 286, 321.
      Kalesse, M., et al. 2001. Chem biochem 2, 709.
      Gerth, K., et al. 1995. J. Antibiot. 48, 973.