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407602 InSolution™ Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor - CAS 509093-47-4 - Calbiochem

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Tableau de caractéristiques principal

CAS #Empirical Formula
509093-47-4C₂₀H₂₁N₅O₄

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407602-5MG
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      Description
      OverviewA cell-permeable benzimidazole compound that acts as a potent and selective inhibitor of interleukin-1 receptor-associated kinases (IC50 = 300 nM and 200 nM for IRAK-1 and -4). Shown to exhibit little activity against a panel of 27 other kinases (IC50 >10 µM), including lck and src. The solid form of this compound (Cat. No. 407601) is also available.
      Catalogue Number407602
      Brand Family Calbiochem®
      SynonymsN-(2-Morpholinylethyl)-2-(3-nitrobenzoylamido)-benzimidazole, N-(1-(2-morpholinoethyl)-1H-benzo[d]imidazol-2-yl)-3-nitrobenzamide
      References
      ReferencesSrivastava, R., et al. 2012. Cancer Res. 72, In press.
      Bhattacharyya, S., et al. 2007. Am. J. Physiol. Gastrointest. Liver Physiol. 293, G429.
      Powers, J.P., et al. 2006. Bioorg. Med. Chem. Lett. 16, 2842.
      Product Information
      CAS number509093-47-4
      FormLiquid
      FormulationA 25 mM (5 mg/506 µL) solution of Interleukin-1 Receptor-Associated-Kinase-1/4 Inhibitor (Cat. No. 407601) in DMSO.
      Hill FormulaC₂₀H₂₁N₅O₄
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetIRAK-1/4
      Primary Target IC<sub>50</sub>300 nM and 200 nM for IRAK-1 and -4
      Purity≥98% by HPLC
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      407602-5MG 04055977211306