Millipore Sigma Vibrant Logo

361552 InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem

The InSolution™ GSK-3 Inhibitor IX, also referenced under CAS 667463-62-9, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: GSK-3α/β
View Products on Sigmaaldrich.com
361552
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
667463-62-9C₁₆H₁₀BrN₃O₂

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
361552-500UG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Ampoule plast. 500 μg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      Catalogue Number361552
      Brand Family Calbiochem®
      References
      ReferencesPolychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Product Information
      CAS number667463-62-9
      ATP CompetitiveY
      FormLiquid
      FormulationA 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
      Hill FormulaC₁₆H₁₀BrN₃O₂
      Chemical formulaC₁₆H₁₀BrN₃O₂
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetGSK-3α/β
      Primary Target IC<sub>50</sub>5 nM against GSK-3α/β
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      361552-500UG 04055977214109

      Documentation

      InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      361552

      Références bibliographiques

      Aperçu de la référence bibliographique
      Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2008 JSW
      DescriptionA cell-permeable, highly potent, selective, reversible, and ATP-competitive inhibitor of GSK-3α/β (IC50 = 5 nM). Specificity was confirmed using various Cdk's (IC50 = 83 nM for Cdk5/p25, 300 nM for Cdk2/cyclin A, 320 nM for Cdk1/cyclin B, and 10 µM for Cdk4/cyclin D1), MAP kinases, PKA, PKC isoforms, PKG, CK, and IRTK (IC50 ≥ 10 µM). Inhibition of GSK by BIO has been shown to result in the activation of the Wnt signaling pathway and sustained pluripotency of human and murine embryonic stem cells (ESCs).
      FormLiquid
      FormulationA 10 mM (500 µg/140 µl) solution of GSK-3 Inhibitor IX (Cat. No. 361550) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      CAS number667463-62-9
      Chemical formulaC₁₆H₁₀BrN₃O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial use, aliquot and refrigerate (4°C).
      Toxicity Carcinogenic / Teratogenic
      ReferencesPolychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935.
      Sato, N., et al. 2004. Nat. Med. 10, 55.
      Meijer, L., et al. 2003. Chem. Biol. 10, 1255.

      Produits & Applications associés

      Suggested Product

      Référence Description  
      361550 GSK-3 Inhibitor IX - CAS 667463-62-9 - Calbiochem Prix & Disponibilité
      361556 GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem Prix & Disponibilité

      Produits associés classés par : Brand Facete

      InSolution™

      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Glycogen Synthase Kinase (GSK) Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Cell Cycle/Cell Division > Cyclin-Dependent Kinase (Cdk) Inhibitors