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196871 InSolution™ BAY 11-7082 - Calbiochem

InSolution™ BAY 11-7082 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: TNF-α-inducible phosphorylation of IκBα
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196871
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₀H₉NO₂S

Prix & Disponibilité

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196871-10MG
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      		 Ampoule plast. 10 mg
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      Description
      Catalogue Number196871
      Brand Family Calbiochem®
      References
      ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
      Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
      Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
      Product Information
      ATP CompetitiveN
      FormLiquid
      FormulationSupplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.
      Hill FormulaC₁₀H₉NO₂S
      Chemical formulaC₁₀H₉NO₂S
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α-inducible phosphorylation of IκBα
      Primary Target IC<sub>50</sub>10 µM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      196871-10MG 04055977206579

      Documentation

      InSolution™ BAY 11-7082 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ BAY 11-7082 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      196871

      Références bibliographiques

      Aperçu de la référence bibliographique
      Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
      Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
      Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.

      Citations

      Titre
    • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
    • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
      		•
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision28-April-2008 RFH
      DescriptionPotential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
      FormLiquid
      FormulationSupplied as a 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196870) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₀H₉NO₂S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Toxicity Irritant
      ReferencesKamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
      Izban, K.F., et al. 2000. Hum. Pathol. 31, 1482.
      Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
      Citation
    • Antje Blumenthal, et al. (2006) The Wingless homologue Wnt5a and its receptor Frizzled-5 regulate inflammatory responses of human mononuclear cells induced by microbial stimulation. Blood In press,.
    • Soonkyu Chung, et al. (2005) Conjugated linoleic acid promotes human adipocyte insulin resistance through NF-κB-dependent cytokine production. Journal of Biological Chemistry 280, 38445-38456.
    • Teresa Sanchez Alcaraz, et al. (2004) Involvement of Glutathione as a Mechanism of Indirect Protection against Spontaneous Ex Vivo Apoptosis Associated with Bovine Leukemia Virus. Journal of Virology 78, 6180-6190.
      		•