171261 Sigma-AldrichInSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem
InSolution™ AMPK Inhibitor, Compound C, CAS 866405-64-3, is a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO.
More>> InSolution™ AMPK Inhibitor, Compound C, CAS 866405-64-3, is a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO. Less<<FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Synonymes: Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I
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Aperçu
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Tableau de caractéristiques principal
| CAS # | Empirical Formula |
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| 866405-64-3 | C₂₄H₂₅N₅O |
Prix & Disponibilité
| Référence | Disponibilité | Conditionnement | Qté | Prix | Quantité | |
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| 171261-1MG |
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Ampoule plast. | 1 mg |
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| Description | |
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| Overview | A cell-permeable pyrrazolopyrimidine compound that inhibits against KDR/VEGFR2, ALK2/BMPR-I, AMPK kinase activity (IC50 = 25.1, 148, and 234.6 nM, respectively), while exhibiting much reduced or little effect toward ALK5/TGFβR-I, ZAPK, Syk, PKCθ, PKA, or JAK3. Shown to block both BMP pathway-dependent dorsoventral development (EC100 = 2.5 µM) and VEGF signaling-dependent intersomitic vessel formation (EC50 = 5 µM) in zebrafish embryo in vivo. Commonly used in combination with AMPK activators AICAR (Cat. No. 123040) and/or Metformin (Cat. No. 317240) for studying AMPK-dependent cellular events in vitro and physiological responses in animals in vivo. |
| Catalogue Number | 171261 |
| Brand Family | Calbiochem® |
| Synonyms | Dorsomorphin, BMP Inhibitor I, AMPK Inhibitor I |
| Product Information | |
|---|---|
| CAS number | 866405-64-3 |
| ATP Competitive | Y |
| Form | Liquid |
| Formulation | Supplied as a 10 mM (1 mg/250 µl) solution of AMPK Inhibitor, Compound C (Cat. No. 171260) in DMSO. |
| Hill Formula | C₂₄H₂₅N₅O |
| Chemical formula | C₂₄H₂₅N₅O |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| Référence | GTIN |
| 171261-1MG | 04055977207170 |
Documentation
InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem FDS
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InSolution™ AMPK Inhibitor, Compound C - CAS 866405-64-3 - Calbiochem Certificats d'analyse
| Titre | Numéro de lot |
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| 171261 |
Références bibliographiques
| Aperçu de la référence bibliographique |
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| Hao, J., et al. 2010. ACS Chem.Biol. 5, 245. Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970. Lee, M., et al. 2003. J. Biol. Chem. 278, 39653. Inoki, K., et al. 2003. Cell 115, 577. Fryer, L.G., 2002. FEBS Lett. 531, 189. Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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