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658411 InSolution™ AG490 - Calbiochem

InSolution™ AG490 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: JAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI

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658411
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₁₇H₁₄N₂O₃

Prix & Disponibilité

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658411-5MG
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      		 Ampoule plast. 5 mg
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      Description
      Catalogue Number658411
      Brand Family Calbiochem®
      SynonymsJAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
      References
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Eriksen, K.W., et al. 2001. Leukemia 15, 787.
      Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
      Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
      Meydan, N., et al. 1996. Nature 379, 645.
      Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Product Information
      FormLiquid
      FormulationA 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
      Hill FormulaC₁₇H₁₄N₂O₃
      Chemical formulaC₁₇H₁₄N₂O₃
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36-45

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Irritant
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      658411-5MG 04055977261608

      Documentation

      InSolution™ AG490 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      InSolution™ AG490 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      658411

      Références bibliographiques

      Aperçu de la référence bibliographique
      Jaleel, M., et al. 2004. Biochemistry 43, 8247.
      Eriksen, K.W., et al. 2001. Leukemia 15, 787.
      Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
      Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
      Meydan, N., et al. 1996. Nature 379, 645.
      Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision20-November-2008 JSW
      SynonymsJAK1 Inhibitor II, JAK2 Inhibitor VI, JAK3 Inhibitor XI
      DescriptionPotent inhibitor of epidermal growth factor receptor kinase autophosphorylation (IC50 = 100 nM). Jak family tyrosine kinase inhibitor. Inhibition of Jak2 by AG 490 selectively blocks leukemic cell growth in vitro and in vivo by inducing programmed cell death, with no harmful effect on normal haematopoiesis. Inhibits the constitutive activation of STAT-3 and IL-2-induced growth of MF tumor cells. AG 490 has also been shown to inhibit the autokinase activity of JAK3. Also reported to inhibit guanylyl cyclase.
      FormLiquid
      FormulationA 100 mM (5 mg/170 µl) solution of AG490 (Cat. No. 658401) in DMSO.
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₇H₁₄N₂O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      Storage Protect from light
      ≤ -70°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Once opened, stock solution is stable for up to 6 months at -70°C.
      Toxicity Irritant
      ReferencesJaleel, M., et al. 2004. Biochemistry 43, 8247.
      Eriksen, K.W., et al. 2001. Leukemia 15, 787.
      Kirken, R.A., et al. 1999. Leukoc. Biol. 65, 891.
      Nielsen, M., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 6764.
      Meydan, N., et al. 1996. Nature 379, 645.
      Gazit, A., et al. 1991. J. Med. Chem. 34, 1896.
      Levitzki, A. 1990. Biochem. Pharmacol. 40, 913.