Millipore Sigma Vibrant Logo

407331 ILK inhibitor, Cpd 22 - Calbiochem

ILK inhibitor, Cpd 22, is a cell-permeable, potent & specific inhibitor of integrin-linked kinase (ILK; IC50 = 600 nM) with anti-proliferative potency against prostrate & breast cancer cell lines.

ILK inhibitor, Cpd 22 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
View Products on Sigmaaldrich.com
407331
Voir les Prix & la Disponibilité

Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₃₀H₃₀F₃N₅O

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
407331-5MG
Récupération des données relatives à la disponibilité...
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Flacon en verre 5 mg
      Prix en cours de récupération
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Description
      OverviewA cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 µM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
      Catalogue Number407331
      Brand Family Calbiochem®
      References
      ReferencesLee, S., et al. 2011. J. Med. Chem. 54, 6364
      Product Information
      FormOff-white powder
      Hill FormulaC₃₀H₃₀F₃N₅O
      Chemical formulaC₃₀H₃₀F₃N₅O
      Quality LevelMQ100
      Applications
      ApplicationILK inhibitor, Cpd 22, is a cell-permeable, potent & specific inhibitor of integrin-linked kinase (ILK; IC50 = 600 nM) with anti-proliferative potency against prostrate & breast cancer cell lines.
      Biological Information
      Purity≥94% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      407331-5MG 04055977188356

      Documentation

      ILK inhibitor, Cpd 22 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      ILK inhibitor, Cpd 22 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      407331

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lee, S., et al. 2011. J. Med. Chem. 54, 6364
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-August-2016 JSW
      DescriptionA cell-permeable, tri-substituted pyrazol compound that acts as a potent and specific integrin-linked kinase (ILK) inhibitor (IC50 = 600 nM). Shown to have high in vitro anti-proliferative potency against prostrate and breast cancer cell lines (IC50 = 1 to 2.5 mM) while sparing normal epithelial cells. Its effect on cancer cells have been attributed to induction of autophagy and apoptosis. Suppresses ILK-mediated phosphorylation of Akt at Ser473 site, thereby down-regulating the downstream targets, such as GSK-3b and myosin light chain. Also causes a transcriptional repression of the transcription factor Y-Box binding protein 1 (YB-1). Exhibits minimum toxicity in mouse model.
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₃₀H₃₀F₃N₅O
      Purity≥94% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesLee, S., et al. 2011. J. Med. Chem. 54, 6364